Pereskia sacharosa Griseb. (Cactaceae) Prevents Lipopolysaccharide-Induced Neuroinflammation in Rodents via Down-Regulating TLR4/CD14 Pathway and GABAA γ2 Activity

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dc.contributor.affiliationDepartamento de Química, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Av. Universidad 940, Ciudad Universitaria, Aguascalientes 20131, Aguascalientes, Mexico
dc.contributor.emailyenny.gomez@edu.uaa.mx (Y.A.G.-A.); esanchez@inprfm.gob.mx, snjedith@gmail.com (E.S.-J.)
dc.creatorPrado-Fernández, María Fernanda
dc.creatorMagdaleno-Madrigal, Víctor Manuel
dc.creatorCabañas-García, Emmanuel
dc.creatorMucio-Ramírez, Samuel
dc.creatorAlmazán-Alvarado, Salvador
dc.creatorPérez-Molphe-Balch, Eugenio
dc.creatorGómez-Aguirre, Yenny Adriana
dc.creatorSánchez-Jaramillo, Edith
dc.creator.identificadorhttps://orcid.org/0009-0007-6247-3283 (Prado-Fernández, María Fernanda)
dc.creator.identificadorhttps://orcid.org/0000-0002-5354-2204 (Magdaleno-Madrigal, Víctor Manuel)
dc.creator.identificadorhttps://orcid.org/0000-0003-3651-5017 (Cabañas-García, Emmanuel)
dc.creator.identificadorhttps://orcid.org/0000-0002-8551-5112 (Mucio-Ramírez, Samuel)
dc.creator.identificadorhttps://orcid.org/0000-0001-6964-8532 (Almazán-Alvarado, Salvador)
dc.creator.identificadorhttps://orcid.org/0000-0003-3394-2486 (Pérez-Molphe-Balch, Eugenio)
dc.creator.identificadorhttps://orcid.org/0000-0002-7244-3383 (Gómez-Aguirre, Yenny Adriana)
dc.creator.identificadorhttps://orcid.org/0000-0002-5560-2645 (Sánchez-Jaramillo, Edith)
dc.date2024
dc.date.accessioned2026-06-24T20:00:32Z
dc.date.issued2024
dc.date.published2024
dc.descriptionPereskia sacharosa Griseb. is a plant used in traditional herbal medicine to treat inflammation. We analyzed the phenolic content of P. sacharosa leaves (EEPs) by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and investigated the anti-inflammatory properties of EEPs and its flavonoid fraction (F10) in animal models subjected to acute neuroinflammation induced by bacterial lipopolysaccharide (LPS). Coronal brain sections of C57BL/6JN male mice or Wistar male rats administered with EEPs or F10 before LPS were subjected to in situ hybridization to determine c-fos and CD14 mRNA levels in the hypothalamus or GABAA γ2 mRNA levels in the hippocampus. Theta oscillations were recorded every 6 h in the hippocampus of Wistar rats. In total, five flavonoids and eight phenolic acids were identified and quantified in P. sacharosa leaves. Either EEPs or F10 crossed the blood-brain barrier (BBB) into the brain and reduced the mRNA expression of c-fos, CD14, and GABAA γ2. A decrease in theta oscillation was observed in the hippocampus of the LPS group, while the F10 + LPS group overrode the LPS effect on theta activity. We conclude that the bioactive compounds of P. sacharosa reduce the central response to inflammation, allowing the early return of ambulatory activity and well-being of the animal.
dc.formatPDF
dc.identifierJC32NC24
dc.identifier.doi10.3390/cimb46070411
dc.identifier.eissn1467-3045
dc.identifier.issn1467-3037
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeSuiza
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/138
dc.identifier.urihttps://doi.org/10.3390/cimb46070411
dc.language.isoeng
dc.publisherMDPI
dc.relation46(7):6885-6902
dc.relation.jnabreviadoCURR ISSUES MOL BIOL
dc.relation.journalCurrent Issues in Molecular Biology
dc.rightsAcceso Cerrado
dc.subject.kwPhenolic compounds
dc.subject.kwLPS
dc.subject.kwTheta oscillation
dc.subject.kwGABAA γ2
dc.subject.kwc-fos
dc.subject.kwCD14 mRNA
dc.titlePereskia sacharosa Griseb. (Cactaceae) Prevents Lipopolysaccharide-Induced Neuroinflammation in Rodents via Down-Regulating TLR4/CD14 Pathway and GABAA γ2 Activity
dc.typeArtículo

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