Broccoli sprouts produce abdominal antinociception but not spasmolytic effects like its bioactive metabolite sulforaphane

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dc.contributor.affiliationNeuropharmacology of Natural Products Laboratory, Neuroscience Research Department, National Institute of Psychiatry "Ramón de la Fuente", Av. México-Xochimilco 101, Col. Sn Lorenzo Huipulco, 14370. México, D. F., Mexico
dc.contributor.emailevag@imp.edu.mx (M.E. González-Trujano)
dc.creatorGuadarrama-Enríquez, O.
dc.creatorGonzález-Trujano, M. E.
dc.creatorVentura-Martínez, R.
dc.creatorRodríguez, R.
dc.creatorÁngeles-López, G. E.
dc.creatorReyes-Chilpa, R.
dc.creatorBaenas, N.
dc.creatorMoreno, D. A.
dc.date2018
dc.date.accessioned2026-06-30T20:05:00Z
dc.date.issued2018
dc.date.published2018
dc.descriptionAbdominal pain is a common health problem that requires efficacious and safe therapy. Broccoli is a rich source of health-promoting bioactive compounds with potential for pain therapy. However, there is a lack of scientific pharmacological evidence to support this. Our aim was to investigate the antinociceptive and spasmolytic activities of broccoli aqueous extracts from seeds, sprouts, and inflorescence, as well as some metabolites. Experiments were done using enteral and parenteral administration in an in vivo model of pain accompanied with an in vitro assay. Data established that sprouts (100 mg/kg, i.p. and 1000 mg/kg, p.o.) produced significant and major antinociceptive effect at similar or even lower doses in comparison to the seeds (125 mg/kg, i.p. and 1000 mg/kg, p.o.) and broccoli heads (250 mg/kg, i.p. and 1000 mg/kg, p.o.). These results resembled the analgesic response observed with the reference drug metamizole (80 mg/kg, i.p.). Chlorogenic acid (CA, 3, 10, 30, and 100 mg/kg, i.p.) and SFN (0.1, 1 and 10 mg/kg, i.p.) were partial responsible antinociceptive metabolites of broccoli. SFN effects involved participation of endogenous opioids, since they were inhibited in the presence of naltrexone (5 mg/kg, s.c.). In the in vitro assay, a significant 80% spasmolytic-like response was reached with SFN alone in comparison to 20% obtained with aqueous extracts of sprouts and seeds. Participation of calcium channels was a mechanism involved in the in vitro response of SFN. In conclusion, broccoli sprouts, SFN and CA are potential nutraceuticals for abdominal pain therapy.
dc.formatPDF
dc.identifierJC13NC18
dc.identifier.doi10.1016/j.biopha.2018.09.010
dc.identifier.eissn1950-6007
dc.identifier.issn0753-3322
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeFrancia
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/166
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2018.09.010
dc.language.isoeng
dc.publisherElsevier
dc.relation107:1770-1778
dc.relation.jnabreviadoBIOMED PHARMACOTHER
dc.relation.journalBiomedicine & Pharmacotherapy
dc.rightsAcceso Cerrado
dc.subject.kwAbdominal analgesia
dc.subject.kwBroccoli
dc.subject.kwOpioids
dc.subject.kwSprouts
dc.subject.kwSulforaphane
dc.titleBroccoli sprouts produce abdominal antinociception but not spasmolytic effects like its bioactive metabolite sulforaphane
dc.typeArtículo

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