Sex and age differences in the antidepressant-like effect of fluoxetine in the forced swim test

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dc.contributor.affiliationDepartamento de Farmacobiología, Cinvestav, México D.F., México
dc.contributor.emailjfernand@cinvestav.mx (A. Fernández-Guasti)
dc.creatorFernández-Guasti, Alonsoes_ES
dc.creatorOlivares-Nazario, Maribeles_ES
dc.creatorReyes, Rebecaes_ES
dc.creatorMartínez-Mota, Lucíaes_ES
dc.date2017
dc.date.accessioned2025-09-22T15:48:12Z
dc.date.accessioned2026-03-27T15:32:38Z
dc.date.available2025-09-22T15:48:12Z
dc.date.issued2017
dc.date.published2017
dc.descriptionThis study compared in males and females of three representative ages: young adults (3-5months old), middle-aged (12-15months old) and senescent (23-25months old) the antidepressant-like effect of fluoxetine (FLX, 5.0 and 10mg/kg) in the forced swim test (FST). Intact (non gonadectomized) rats were evaluated. Young adult females were chosen in proestrus/estrus or in metestrus/diestrus, while middle-aged and senescent females were selected in metestrus/diestrus. Locomotion and motor coordination were also recorded. Under basal conditions (without FLX), young adult and middle-aged females showed less immobility than males. This sex difference disappeared at senescence because males diminished their levels of immobility. Thus, senescent males showed lower immobility than middle-aged and young males. FLX (5 and 10mg/kg) produced similar actions in young females irrespective of their estrous cycle phase, therefore, these subgroups were pooled in a single one. Young adult and middle aged females clearly responded to 5 and 10mg/kg of FLX with a reduction in immobility, while young adult and middle-aged males only did to 10mg/kg. In senescent females 10mg/kg FLX reduced immobility. Remarkably, in senescent males this FLX dose did not produce an antidepressant-like effect. FLX marginally affected locomotion; however, at its highest dose (10mg/kg), and only in senescent males, interfered with motor coordination tested in the rotarod. These data show that sex and aging influence behavioral despair without treatment and after FLXes_ES
dc.formatPDFes_ES
dc.identifier.doi10.1016/j.pbb.2016.01.011
dc.identifier.eissn1873-5177
dc.identifier.issn0091-3057
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeEstados Unidos
dc.identifier.urihttp://dx.doi.org/10.1016/j.pbb.2016.01.011
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8415
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation152:81-89
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAV
dc.relation.journalPharmacology, Biochemistry, and Behavior
dc.rightsAcceso Cerradoes_ES
dc.subject.kwFluoxetine
dc.subject.kwDepressive-like behavior
dc.subject.kwForced swim test
dc.subject.kwSex and age differences
dc.titleSex and age differences in the antidepressant-like effect of fluoxetine in the forced swim testes_ES
dc.typeArtículoes_ES

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