Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings

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dc.contributor.affiliationDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
dc.contributor.emaileva.velthorst@mssm.edu.
dc.creatorVelthorst, Evaes_ES
dc.creatorMollon, Josephinees_ES
dc.creatorMurray, Robin M.es_ES
dc.creatorHaan, Lieuwe dees_ES
dc.creatorGermeys, Inez Myines_ES
dc.creatorGlahn, David C.es_ES
dc.creatorArango, Celsoes_ES
dc.creatorVen, Els van deres_ES
dc.creatorForti, Marta Dies_ES
dc.creatorBernardo, Migueles_ES
dc.creatorGuloksuz, Sinanes_ES
dc.creatorDelespaul, Philippees_ES
dc.creatorMezquida, Giselaes_ES
dc.creatorAmoretti, Silviaes_ES
dc.creatorBobes, Julioes_ES
dc.creatorSaiz, Pilar A.es_ES
dc.creatorGarcía-Portilla, María Pazes_ES
dc.creatorSantos, José Luises_ES
dc.creatorJiménez-López, Estelaes_ES
dc.creatorSanjuan, Julioes_ES
dc.creatorAguilar, Eduardo J.es_ES
dc.creatorArrojo, Manueles_ES
dc.creatorCarracedo, Angeles_ES
dc.creatorLópez, Gonzaloes_ES
dc.creatorGonzález-Peñas, Javieres_ES
dc.creatorParellada, Maraes_ES
dc.creatorAtbaşoğlu, Cemes_ES
dc.creatorSaka, Meram Canes_ES
dc.creatorÜçok, Alpes_ES
dc.creatorAlptekin, Köksales_ES
dc.creatorAkdede, Bernaes_ES
dc.creatorBinbay, Tolgaes_ES
dc.creatorAltınyazar, Vesilees_ES
dc.creatorUlaş, Halises_ES
dc.creatorYalınçetin, Bernaes_ES
dc.creatorGümüş-Akay, Güvemes_ES
dc.creatorBeyaz, Burçin Cihanes_ES
dc.creatorSoygür, Haldunes_ES
dc.creatorŞahin Cankurtaran, Eylemes_ES
dc.creatorUlusoy Kaymak, Semraes_ES
dc.creatorMaric, Nadja P.es_ES
dc.creatorMihaljevic, Marina M.es_ES
dc.creatorPetrovic, Sanja Andrices_ES
dc.creatorMirjanic, Tijanaes_ES
dc.creatorDel-Ben, Cristina Martaes_ES
dc.creatorFerraro, Lauraes_ES
dc.creatorGayer-Anderson, Charlottees_ES
dc.creatorJones, Peter B.es_ES
dc.creatorJongsma, Hannah E.es_ES
dc.creatorKirkbride, James B.es_ES
dc.creatorCascia, Caterina Laes_ES
dc.creatorLasalvia, Antonioes_ES
dc.creatorTosato, Sarahes_ES
dc.creatorLlorca, Pierre-Micheles_ES
dc.creatorMenezes, Paulo Rossies_ES
dc.creatorMorgan, Craiges_ES
dc.creatorQuattrone, Diegoes_ES
dc.creatorMenchetti, Marcoes_ES
dc.creatorSelten, Jean-Paules_ES
dc.creatorSzöke, Andreies_ES
dc.creatorTarricone, Ilariaes_ES
dc.creatorTortelli, Andreaes_ES
dc.creatorMcGuire, Philipes_ES
dc.creatorValmaggia, Luciaes_ES
dc.creatorKempton, Matthew, J.es_ES
dc.creatorGaag, Mark van deres_ES
dc.creatorRiecher-Rössler, Anitaes_ES
dc.creatorBressan, Rodrigo A.es_ES
dc.creatorBarrantes-Vidal, Neuses_ES
dc.creatorNelson, Barnabyes_ES
dc.creatorMcGorry, Patrickes_ES
dc.creatorPantelis, Chrises_ES
dc.creatorKrebs, Marie-Odilees_ES
dc.creatorRuhrmann, Stephanes_ES
dc.creatorSachs, Gabrielees_ES
dc.creatorRutten, Bart P. F.es_ES
dc.creatorOs, Jim vanes_ES
dc.creatorAlizadeh, Behrooz Z.es_ES
dc.creatorAmelsvoort, Therese vanes_ES
dc.creatorBartels-Velthuis, Agna A.es_ES
dc.creatorBruggeman, Richardes_ES
dc.creatorBeveren, Nico J. vanes_ES
dc.creatorLuykx, Jurjen J.es_ES
dc.creatorCahn, Wiepkees_ES
dc.creatorSimons, Claudia J. P.es_ES
dc.creatorKahn, Rene S.es_ES
dc.creatorSchirmbeck, Frederikees_ES
dc.creatorWinkel, Ruud vanes_ES
dc.creatorReichenberg, Abrahames_ES
dc.creatorEU-GEI High Risk Study:es_ES
dc.creatorCalem, Mariaes_ES
dc.creatorTognin, Stefaniaes_ES
dc.creatorModinos, Gemmaes_ES
dc.creatorPisani, Saraes_ES
dc.creatorKraan, Tamar C.es_ES
dc.creatorDam, Daniella S. vanes_ES
dc.creatorBurger, Nadinees_ES
dc.creatorAmminger, G. Paules_ES
dc.creatorPolitis, Athenaes_ES
dc.creatorGoodall, Joannees_ES
dc.creatorBorgwardt, Stefanes_ES
dc.creatorStuderus, Eriches_ES
dc.creatorGadelha, Aryes_ES
dc.creatorBrietzke, Elisaes_ES
dc.creatorAsevedo, Gracciellees_ES
dc.creatorAsevedo, Elsones_ES
dc.creatorZugman, Andrees_ES
dc.creatorDomínguez-Martínez, Tecellies_ES
dc.creatorMonsonet, Maneles_ES
dc.creatorCristóbal-Narváez, Paulaes_ES
dc.creatorRacioppi, Annaes_ES
dc.creatorKwapil, Thomas R.es_ES
dc.creatorKazes, Mathildees_ES
dc.creatorDaban, Clairees_ES
dc.creatorBourgin, Juliees_ES
dc.creatorGay, Olivieres_ES
dc.creatorMam-Lam-Fook, Céliaes_ES
dc.creatorNordholm, Dortees_ES
dc.creatorRander, Lassees_ES
dc.creatorKrakauer, Kristinees_ES
dc.creatorBirkedal Glenthøj, Louisees_ES
dc.creatorGlenthøj, Birtees_ES
dc.creatorGebhard, Dominikaes_ES
dc.creatorArnhold, Juliaes_ES
dc.creatorKlosterkötter, Joachimes_ES
dc.creatorLasser, Irises_ES
dc.creatorWinklbaur, Bernadettees_ES
dc.date2021
dc.date.accessioned2024-05-08T17:30:26Z
dc.date.accessioned2026-03-27T15:30:06Z
dc.date.available2024-05-08T17:30:26Z
dc.date.issued2021
dc.date.published2021
dc.descriptionImportant questions remain about the profile of cognitive impairment in psychotic disorders across adulthood and illness stages. The age-associated profile of familial impairments also remains unclear, as well as the effect of factors, such as symptoms, functioning, and medication. Using cross-sectional data from the EU-GEI and GROUP studies, comprising 8455 participants aged 18 to 65, we examined cognitive functioning across adulthood in patients with psychotic disorders (n = 2883), and their unaffected siblings (n = 2271), compared to controls (n = 3301). An abbreviated WAIS-III measured verbal knowledge, working memory, visuospatial processing, processing speed, and IQ. Patients showed medium to large deficits across all functions (ES range = -0.45 to -0.73, p < 0.001), while siblings showed small deficits on IQ, verbal knowledge, and working memory (ES = -0.14 to -0.33, p < 0.001). Magnitude of impairment was not associated with participant age, such that the size of impairment in older and younger patients did not significantly differ. However, first-episode patients performed worse than prodromal patients (ES range = -0.88 to -0.60, p < 0.001). Adjusting for cannabis use, symptom severity, and global functioning attenuated impairments in siblings, while deficits in patients remained statistically significant, albeit reduced by half (ES range = -0.13 to -0.38, p < 0.01). Antipsychotic medication also accounted for around half of the impairment in patients (ES range = -0.21 to -0.43, p < 0.01). Deficits in verbal knowledge, and working memory may specifically index familial, i.e., shared genetic and/or shared environmental, liability for psychotic disorders. Nevertheless, potentially modifiable illness-related factors account for a significant portion of the cognitive impairment in psychotic disorders.es_ES
dc.formatPDFes_ES
dc.identifierJC85DIEP21es_ES
dc.identifier.doi10.1038/s41380-020-00969-z
dc.identifier.eissn1476-5578
dc.identifier.issn1359-4184
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeInglaterra
dc.identifier.urihttps://doi.org/10.1038/s41380-020-00969-z
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/7964
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.relation26(8):4529-4543
dc.relation.jnabreviadoMolec Psychiat
dc.relation.journalMolecular Psychiatry
dc.rightsAcceso Cerradoes_ES
dc.titleCognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblingses_ES
dc.typeArtículoes_ES

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