The neuronal cytoskeleton as a potential therapeutical target in neurodegenerative diseases and schizophrenia

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dc.contributor.affiliationInstituto Nacional de Psiquiatría, Departamento de Neurofarmacología, Subdirección de Investigaciones Clínicas, México, D.F., Méxicoes_ES
dc.contributor.emailbekin@imp.edu.mxes_ES
dc.creatorBenitez-King, G.
dc.creatorRamírez-Rodríguez, G.
dc.creatorOrtíz, L.
dc.creatorMeza, I.
dc.creator.identificador"BEKG540727MDFNNL05">Benítez King, Gloria A.es_ES
dc.date.accessioned2017-06-29T04:32:34Z
dc.date.accessioned2026-03-27T14:35:34Z
dc.date.available2017-06-29T04:32:34Z
dc.date.issued2004es_ES
dc.date.published2004es_ES
dc.description.abstractotrodiomaThe cytoskeleton plays a key role in maintaining the highly asymmetrical shape and structural polarity of neurons that are essential for neuronal physiology. Cytoskeletal reorganization plays a key role in neuritogenesis. In neurodegenerative diseases, the cytoskeleton is abnormally assembled and impairment of neurotransmission occurs. In Alzheimer's disease, abundant amyloid plaques and neurofibrillary tangles constitute the two major neuropathologic alterations present in the brain. Neurofibrillary tangles are formed of paired helical filaments consisting nearly entirely of the microtubule-associated protein tau. Under normal conditions tau binds to microtubules, stabilizing neuron structure and integrity. Hyperphosphorylation of tau is assumed to be the cause of formation of paired helical filaments. Another example of cytoskeletal abnormalities present in neurodegenerative diseases are the Lewy bodies considered as cytopathologic markers of Parkinson's disease. Lewy bodies are constituted of tubulin, MAP1, and MAP2. Neuronal shape, loss of dendrites and spines, as well as irregular distribution of neuronal elongations occur in specific brain areas of schizophrenic patients. Increase in non-phosphorylated MAP2 and MAP1B at hippocampus has been suggested as responsible for somatodendritic and cytoarchitectural abnormalities found in schizophrenia. In addition, neurofibrillary tangles are more frequent among schizophrenic patients who received pharmacologic antipsychotic treatment. Cumulative evidence suggests that neurodegenerative diseases and psychiatric illnesses are associated with cytoskeletal alterations in neurons that, in turn, loose synaptic connectivity and the ability to transmit incoming axonal information to the somatodendritic domain. We will review evidence supporting that the neuronal cytoskeleton is disrupted in neurodegenerative and some psychiatric diseases, and therefore could be a target for drug therapy. In addition, current data indicating that melatonin, a hormone secreted by the pineal gland, promotes neuritogenesis through cytoskeletal rearrangements and in addition to the potential therapeutic use of melatonin in neurodegenerative diseases will be discussed.es_ES
dc.description.monthDices_ES
dc.identifier423es_ES
dc.identifier.citationJosé Artemio Hernández Martínezes_ES
dc.identifier.issn1568-007Xes_ES
dc.identifier.numero6es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion515-533es_ES
dc.identifier.placePaíses bajoses_ES
dc.identifier.urihttp://doi.org/10.2174/1568007043336761es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/5112
dc.identifier.volumen3es_ES
dc.language.isoenges_ES
dc.relation3 (6) 515-533 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoCURR DRUG TARGETS CNS NEUROL DISORDes_ES
dc.relation.journalCurrent drug targets. CNS and neurological disorderses_ES
dc.rightsacceso cerradoes_ES
dc.titleThe neuronal cytoskeleton as a potential therapeutical target in neurodegenerative diseases and schizophreniaes_ES
dc.typearticlees_ES

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