Non-Painful Peripheral Inflammation Blocks Conditioned Place-Preference to Morphine and Nicotine through an Ibuprofen-Sensitive and an Ibuprofen Insensitive Pathway

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dc.contributor.affiliationDepartmento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México
dc.contributor.emailgoac@unam.mx
dc.creatorSotomayor-Sobrino, Marco Antonio
dc.creatorOchoa-Aguilar, Abraham
dc.creatorTenorio, Eda Patricia
dc.creatorLeón-Olea, Martha
dc.creatorVelasco-González, Roberto
dc.creatorLuna-Mendoza, Israel
dc.creatorGómez-Acevedo, Claudia
dc.date2018
dc.date.accessioned2026-07-09T18:58:02Z
dc.date.issued2018
dc.date.published2018
dc.descriptionThe field of neuroimmunology has expanded in recent years providing new insights and therapies into pathologies like stroke, autism, and depression. However, few works explore the relationship between inflammatory stimuli and motivation. Thus, the aim of this study was to determine how non-painful inflammatory stimuli affect reward. To test reward-response, we used the morphine and the nicotine induced conditioned place-preference and place-aversion model in rats with non-painful inflammation. The following inflammatory models were used: non-painful infectious inflammation: 24 hrs prior to conditioning sessions, an injection with Calmette-Guerin bacillus (CGB) 1 × 107 cfu, ip, was administered. Non-painful non-infectious inflammation: 24 hrs prior to conditioning sessions, rats’ sciatic nerve was blocked and cut, followed by the injection of carrageenan (750 μl) in the paw. We then measured the cytokine concentration to determine the inflammatory profile of each of our models. Finally, we administered ibuprofen to determine if it could prevent the effect of inflammation over conditioned place-preference. We show that carrageenan significantly reduced the morphine-induced reward. Non-painful inflammatory stimulus, CGB and denervation + carrageenan, inhibit the conditioned place-preference to morphine and nicotine, CGB also block conditioned place-aversion to nicotine; carrageenan has no effect on CPA. The administration of ibuprofen reinstates conditioned place-preference to morphine and nicotine in the carrageenan model, but has no effect in the CGB model; finally ibuprofen has no effect on CPA. Our data suggest that non-painful-inflammatory stimuli inhibit the reward system, independent of cytokine concentration. Furthermore, the administration of a PGE 2 inhibitor can importantly modulate this phenomenon.
dc.formatPDF
dc.identifierJC35NC18
dc.identifier.doi10.4236/jbbs.2018.82004
dc.identifier.eissn2160-5874
dc.identifier.issn2160-5866
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeEstados Unidos
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/191
dc.identifier.urihttps://doi.org/10.4236/jbbs.2018.82004
dc.language.isoeng
dc.publisherScientific Research Publishing
dc.relation8:57-76
dc.relation.jnabreviadoJ BEHAV BRAIN SCI
dc.relation.journalJournal of Behavioral and Brain Science
dc.rightsAcceso Cerrado
dc.subject.kwReward
dc.subject.kwAddiction
dc.subject.kwPain
dc.subject.kwInflammation
dc.subject.kwProstaglandins
dc.subject.kwInterferon
dc.titleNon-Painful Peripheral Inflammation Blocks Conditioned Place-Preference to Morphine and Nicotine through an Ibuprofen-Sensitive and an Ibuprofen Insensitive Pathway
dc.typeArtículo

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