In vitro effect of diazoxon on cell signaling and second messengers in Nile tilapia (Oreochromis niloticus) leukocytes

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dc.contributor.affiliationPrograma de Maestría en Ciencias Biológico Agropecuarias, Universidad Autónoma de Nayarit, Carretera Tepic-Compostela Km. 9. Xalisco, Nayarit C.P. 63780, México
dc.contributor.emailivan_giron@hotmail.com (Manuel Iván Girón-Pérez)
dc.creatorCamacho-Pérez, Milton Rafael
dc.creatorDíaz-Resendiz, Karina Janice Guadalupe
dc.creatorOrtiz-Butrón, Rocío
dc.creatorCovantes-Rosales, Carlos Eduardo
dc.creatorBenitez-Trinidad, Alma Betsaida
dc.creatorGirón-Pérez, Daniel Alberto
dc.creatorToledo-Ibarra, Gladys Alejandra
dc.creatorPavón, Lenin
dc.creatorGirón-Pérez, Manuel Iván
dc.date2024
dc.date.accessioned2026-06-16T20:08:28Z
dc.date.issued2024
dc.date.published2024
dc.descriptionThe physiological and molecular responses of leukocytes are altered by organophosphate pesticides. Some reports have shown that diazinon causes immunotoxic effects; diazoxon, the oxon metabolite of diazinon, is attributed to influence the immune response by affecting the leukocyte cholinergic system. In this study, the in vitro effects of diazoxon on molecules involved in cell signaling (cAMP, IP3, DAG, JAK1, and STAT3), which play a crucial role in the activation, differentiation, and survival of leukocytes, were evaluated. Data indicate that diazoxon leads to a decrease in cAMP concentration and an increase in basal IP3 levels. However, diazoxon does not affect basal levels of JAK1 and STAT3 phosphorylation. Instead, diazoxon inhibits leukocyte responsiveness to phorbol myristate acetate and ionomycin, substances that, under normal conditions, enhance JAK/STAT signaling. These findings demonstrate that diazoxon significantly affects key molecular parameters related to cell signaling
dc.formatPDF
dc.identifierJC04NC24
dc.identifier.doi10.1093/jleuko/qiae081
dc.identifier.eissn1938-3673
dc.identifier.issn0741-5400
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeInglaterra
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/103
dc.identifier.urihttps://doi.org/10.1093/jleuko/qiae081
dc.language.isoeng
dc.publisherOxford University Press
dc.relation116(1):77-83
dc.relation.jnabreviadoJ LEUKOC BIOL
dc.relation.journalJournal of Leukocyte Biology
dc.rightsAcceso Cerrado
dc.subject.kwImmunotoxicity
dc.subject.kwLeukocytes
dc.subject.kwOrganophosphorus pesticides
dc.subject.kwSignal transduction
dc.titleIn vitro effect of diazoxon on cell signaling and second messengers in Nile tilapia (Oreochromis niloticus) leukocytes
dc.typeArtículo

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