Expression of IL-8, IL-6 and IL-1β in tears as a main characteristic of the immune response in human microbial keratitis

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dc.contributor.affiliationCornea and Refractive Surgery Department, and Research Unit, Institute of Ophthalmology “Conde de Valenciana Foundation”, Mexico 06800, DF, Mexicoes_ES
dc.contributor.emailcsantivaldes@hotmail.comes_ES
dc.creatorSantacruz, Concepcion
dc.creatorLinares, Marisela
dc.creatorGarfias, Yonathan
dc.creatorLoustaunau, Luisa M.
dc.creatorPavon, Lenin
dc.creatorPerez-Tapia, Sonia Mayra
dc.creatorJimenez-Martinez, Maria C.
dc.creator.identificador"http://orcid.org/0000-0003-4299-6179">Santacruz Valdes, Concepciones_ES
dc.creator.identificador"http://orcid.org/0000-0003-3753-1035">Garfias, Yonathanes_ES
dc.creator.identificador"PETS750209MVZRPN04">Perez-Tapia, Sonia Mayraes_ES
dc.date.accessioned2017-06-29T03:49:20Z
dc.date.accessioned2026-03-27T14:32:57Z
dc.date.available2017-06-29T03:49:20Z
dc.date.issued2015es_ES
dc.date.published2015es_ES
dc.description.abstractotrodiomaCorneal infections are frequent and potentially vision-threatening diseases, and despite the significance of the immunological response in animal models of microbial keratitis (MK), it remains unclear in humans. The aim of this study was to describe the cytokine profile of tears in patients with MK. Characteristics of ocular lesions such as size of the epithelial defect, stromal infiltration, and hypopyon were analyzed. Immunological evaluation included determination of interleukine (IL)-1β, IL-6, IL-8, IL-10, IL-12 and tumor necrosis factor (TNF)-α in tear samples obtained from infected eyes of 28 patients with MK and compared with their contralateral non-infected eyes. Additionally, frequency of CD4+, CD8+, CD19+ and CD3-CD56+ cells was also determined in peripheral blood mononuclear cells in patients with MK, and compared with 48 healthy controls. Non-significant differences were observed in the size of the epithelial defect, stromal infiltration, and hypopyon. Nevertheless, we found an immunological profile apparently related to MK etiology. IL-8 > IL-6 in patients with bacterial keratitis; IL-8 > IL-6 > IL-1β and increased frequency of circulating CD3-CD56+ NK cells in patients with gram-negative keratitis; and IL-8 = IL-6 > IL-1β in patients with fungal keratitis. Characterization of tear cytokines from patients with MK could aid our understanding of the immune pathophysiological mechanisms underlying corneal damage in humans.es_ES
dc.description.monthMares_ES
dc.identifier2714es_ES
dc.identifier.citationJuan Carlos Bautista Ramírezes_ES
dc.identifier.doi10.3390/ijms16034850.es_ES
dc.identifier.issn1422-0067es_ES
dc.identifier.numero3es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion4850-4864es_ES
dc.identifier.placeSuizaes_ES
dc.identifier.urihttps://doi.org/10.3390/ijms16034850
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/4563
dc.identifier.volumen16es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation16(3):4850-4864es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoINT J MOL SCIes_ES
dc.relation.journalInternational Journal of Molecular Scienceses_ES
dc.rightsAcceso Cerradoes_ES
dc.subject.koMicrobial keratitises_ES
dc.subject.koCytokines; IL-1βes_ES
dc.subject.koIL-6es_ES
dc.subject.koIL-8es_ES
dc.subject.koNK cellses_ES
dc.subject.koHumanes_ES
dc.titleExpression of IL-8, IL-6 and IL-1β in tears as a main characteristic of the immune response in human microbial keratitises_ES
dc.typeArtículoes_ES

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