Antidepressant- and Anxiolytic-like Effects of Pomegranate: Is It Acting by Common or Well-Known Mechanisms of Action?

Simple item page
dc.contributor.affiliationLaboratorio de Neuropsicofarmacología, Dirección de Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Mexico City 14370, Mexico
dc.contributor.emailestrada@inprf.gob.mx, monesca71@gmail.com (Erika Estrada-Camerena)
dc.creatorEstrada-Camerena, Erika
dc.creatorLópez-Rubalcava, Carolina
dc.creatorVega-Rivera, Nelly
dc.creatorGonzález-Trujano, María
dc.creator.identificadorhttps://orcid.org/0000-0001-6634-7494 (Estrada-Camerena, Erika)
dc.creator.identificadorhttps://orcid.org/0000-0002-9562-7193 (López-Rubalcava, Carolina)
dc.date2024
dc.date.accessioned2026-06-18T21:27:20Z
dc.date.issued2024
dc.date.published2024
dc.descriptionThe pharmacological effects of pomegranates have been described considering metabolic aspects such as hypoglycemic and hypolipidemic activities. The pomegranate extract has activity on the central nervous system (CNS) as a natural antidepressant and anxiolytic. The chemical composition of pomegranates is complex since the bioactive compounds are multiple secondary metabolites that have been identified in the extracts derived from the peel, seed, flowers, leaves, or in their combination; so, it has not been easy to identify an individual compound as responsible for its observed pharmacological properties. From this point of view, the present review analyzes the effects of crude extracts or fractions of pomegranates and their possible mechanisms of action concerning antidepressant- and anxiolytic-like effects in animal models. Serotonin receptors, estrogen receptors, the peroxisome proliferator-activated receptor gamma (PPARγ), or monoamine oxidase enzymes, as well as potent antioxidant and neuroplasticity properties, have been described as possible mediators involved in the antidepressant- and anxiolytic-like behaviors after pomegranate treatment. The pharmacological effects observed on the CNS in experimental models associated with a specific stress level suggest that pomegranates could simultaneously modulate the stress response by activating several targets. For the present review, scientific evidence was gathered to integrate it and suggest a possible pathway for mediators to be involved in the mechanisms of action of the pomegranate's antidepressant- and anxiolytic-like effects. Furthermore, the potential benefits are discussed on comorbid conditions with anxiety and depression, such as perimenopause transition and pain.
dc.formatPDF
dc.identifierJC16NC24
dc.identifier.doi10.3390/plants13162205
dc.identifier.eissn2223-7747
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeSuiza
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/120
dc.identifier.urihttps://doi.org/10.3390/plants13162205
dc.language.isoeng
dc.publisherMDPI
dc.relation13(16):2205
dc.relation.jnabreviadoPLANTS (BASEL)
dc.relation.journalPlants
dc.rightsAcceso Cerrado
dc.subject.kwAnxiety
dc.subject.kwDepression
dc.subject.kwEstrogen receptors
dc.subject.kwSerotonin
dc.subject.kwOxidative stress
dc.subject.kwPeroxisome proliferator-activated receptor gamma
dc.subject.kwPerimenopause
dc.subject.kwPomegranate
dc.titleAntidepressant- and Anxiolytic-like Effects of Pomegranate: Is It Acting by Common or Well-Known Mechanisms of Action?
dc.typeArtículo

Files

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

Artículos de revista