Chronic Deep Brain Stimulation of the Hypothalamic Nucleus in Wistar Rats Alters Circulatory Levels of Corticosterone and Proinflammatory Cytokines 

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dc.contributor.affiliationNatl Inst Neurol & Neurosurg Manuel Velasco Suare, Lab Neuroimmunoendocrinol, Ave Insurgentes Sur 3877, Mexico City 14269, DF, Mexico.es_ES
dc.contributor.emailmariluci_guirre@hotmail.com; lkuriaki@imp.edu.mx es_ES
dc.creatorCalleja-Castillo, Juan Manuel
dc.creatorDe La Cruz-Aguilera, Dora Luz
dc.creatorManjarrez, Joaquin
dc.creatorVelasco-Velazquez, Marco Antonio
dc.creatorMorales-Espinoza, Gabriel
dc.creatorMoreno-Aguilar, Julia
dc.creatorHernandez, Maria Eugenia
dc.creatorAguirre-Cruz, Lucinda
dc.creatorPavon, Lenin
dc.creator.identificadorHEGE630202MDFRTG02>Hernandez, Maria Eugeniaes_ES
dc.creator.identificadorAUCL581114MDFGRC08>Aguirre Cruz, Lucindaes_ES
dc.creator.identificadorhttp://orcid.org/0000-0002-6067-6868>Pavon, Lenines_ES
dc.date.accessioned2017-06-29T03:43:10Z
dc.date.accessioned2026-03-27T14:33:59Z
dc.date.available2017-06-29T03:43:10Z
dc.date.issued2013es_ES
dc.date.published2013es_ES
dc.description.abstractotrodiomaDeep brain stimulation (DBS) is a therapeutic option for several diseases, but its effects on HPA axis activity and systemic inflammation are unknown. This study aimed to detect circulatory variations of corticosterone and cytokines levels in Wistar rats, after 21 days of DBS-at the ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl), unilateral cervical vagotomy (UCVgX), or UCVgX plus DBS. We included the respective control (C) and sham (S) groups (n = 6 rats per group). DBS treated rats had higher levels of TNF-alpha (120%; P < 0.01) and IFN-gamma (305%; P < 0.001) but lower corticosterone concentration (48%; P < 0.001) than C and S. UCVgX animals showed increased corticosterone levels (154%; P < 0.001) versus C and S. UCVgX plus DBS increased IL-1 beta (402%; P < 0.001), IL-6 (160%; P < 0.001), and corsticosterone (178%; P < 0.001 versus 48%; P < 0.001) compared with the C and S groups. Chronic DBS at VMHvl induced a systemic inflammatory response accompanied by a decrease of HPA axis function. UCVgX rats experienced HPA axis hyperactivity as result of vagus nerve injury; however, DBS was unable to block the HPA axis hyperactivity induced by unilateral cervical vagotomy. Further studies are necessary to explore these findings and their clinical implication.es_ES
dc.description.monthSepes_ES
dc.identifier2593es_ES
dc.identifier.citationMaría Guadalupe Camal Ibáñezes_ES
dc.identifier.doi10.1155/2013/698634 es_ES
dc.identifier.eissn1740-2530es_ES
dc.identifier.issn1740-2522es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion1-10es_ES
dc.identifier.placeNew Yorkes_ES
dc.identifier.urihttps://doi.org/10.1155/2013/698634es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/4442
dc.language.isoenges_ES
dc.publisherHindawi Publishing Corporation, 410 Park Avenue, 15TH Floor, #287 PMB, New York, NY 10022 USA es_ES
dc.relation1-10p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoCLIN DEV IMMUNOLes_ES
dc.relation.journalClinical & developmental immunologyes_ES
dc.rightsacceso cerradoes_ES
dc.titleChronic Deep Brain Stimulation of the Hypothalamic Nucleus in Wistar Rats Alters Circulatory Levels of Corticosterone and Proinflammatory Cytokines es_ES
dc.typeartículoes_ES

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