Relationship between inflammatory markers in human olfactory neural progenitor cells and antidepressant response

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dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, San Lorenzo Huipulco, Tlalpan, Ciudad de México, México
dc.contributor.emailflores_ramos@hotmail.com (F.-R. Mónica)
dc.creatorFlores-Ramos, Mónica
dc.creatorRamírez-Rodríguez, Gerardo Bernabé
dc.creatorGuiza Zayas, Rodrigo
dc.creatorSolares-Bravo, Melissa
dc.creatorRodríguez-Bores, Lorena
dc.date2024
dc.date.accessioned2026-06-05T19:08:14Z
dc.date.issued2024
dc.date.published2024
dc.descriptionResponse to antidepressants is related to hippocampal neurogenesis integrity, a process mediated by neurotrophins, such as Brain Derived Neurotrophic Factor (BDNF). In turn, pro-inflammatory state appears to reduce neurogenesis, and has been associated with refractory depressive states. We propose to analyze the human neural progenitor cells derived from the olfactory epithelium (HNPCs-OE) as an indicator of neurogenesis in humans. Therefore, we compared the number and content of HNPCs-OE in depressed patients taking antidepressants, according to response to treatment. Twenty depressed patients were followed during eight weeks after antidepressant treatment was prescribed. At the end evaluation they were divided in two groups according to Hamilton depression rating scale (HDRS) scores: responders and non-responders. We compared the number and components of HNPCs-OE between groups and observed an elevation of interleukine-8 in those patients who do not achieve response to treatment, BDNF levels were no related to antidepressant response.
dc.formatPDF
dc.identifierOE07IC2025
dc.identifier.doi10.1016/j.jpsychires.2024.01.047
dc.identifier.eissn1879-1379
dc.identifier.issn0022-3956
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeInglaterra
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/67
dc.identifier.urihttps://doi.org/10.1016/j.jpsychires.2024.01.047
dc.language.isoeng
dc.publisherPergamon Press
dc.relation171:277-285
dc.relation.jnabreviadoJ PSYCHIATR RES
dc.relation.journalJournal of Psychiatric Research
dc.rightsAcceso Cerrado
dc.subject.kwMajor depressive disorder
dc.subject.kwAntidepressant
dc.subject.kwResponse to treatment
dc.subject.kwInterleukine-8
dc.subject.kwInflammation
dc.titleRelationship between inflammatory markers in human olfactory neural progenitor cells and antidepressant response
dc.typeArtículo

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