Insular cortex lesion diminishes neuropathic and inflammatory pain-like behaviours.

Simple item page
dc.contributor.affiliationLaboratorio de Neurofisiología Integrativa, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente, México DF, Mexico.es_ES
dc.creatorCoffeen, Ulises
dc.creatorOrtega-Legaspi, J. Manuel
dc.creatorLópez-Muñoz, Francisco J.
dc.creatorSimón-Arceo, Karina
dc.creatorJaimes, Orlando
dc.creatorPellicer, Francisco
dc.creator.identificador"COMU770605HDFFDL05">Coffeen Medina, Ulises R.es_ES
dc.date.accessioned2017-06-30T03:58:25Z
dc.date.accessioned2026-03-27T15:24:41Z
dc.date.available2017-06-30T03:58:25Z
dc.date.issued2011es_ES
dc.date.published2011es_ES
dc.description.abstractotrodiomaInjury to the insular cortex in humans produces a lack of appropriate response to pain. Also, there is controversial evidence on the lateralization of pain modulation. The aim of this study was to test the effect of insular cortex lesions in three models of pain in the rat. An ipsilateral, contralateral or bilateral radiofrequency lesion of the rostral agranular insular cortex (RAIC) was performed 48h prior to acute, inflammatory or neuropathic pain models in all the experimental groups. Acute pain was tested with paw withdrawal latency (PWL) after thermal stimulation. Inflammation was induced with carrageenan injected in the paw and PWL was tested 1h and 24h afterwards. Neuropathic pain was tested after ligature of the sciatic nerve by measuring mechanical nociceptive response after stimulation with the von Frey filaments. Another model of neuropathy consisted of thermo stimulation followed by right sciatic neurectomy prior to the recording of autotomy behaviour. Acute pain was not modified by the RAIC lesion. All the RAIC lesion groups showed diminished pain-related behaviours in inflammatory (increased PWL) and neuropathic models (diminished mechanical nociceptive response and autotomy score). The lesion of the RAIC produces a significant decrease in pain-related behaviours, regardless of the side of the lesion. This is a clear evidence that the RAIC plays an important role in the modulation of both inflammatory and neuropathic - but not acute - pain.es_ES
dc.description.monthFebes_ES
dc.identifier2422es_ES
dc.identifier.citationJuan Carlos Bautista Ramírezes_ES
dc.identifier.doi10.1016/j.ejpain.2010.06.007es_ES
dc.identifier.eissn1532-2149es_ES
dc.identifier.issn1090-3801es_ES
dc.identifier.numero2es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion132-138es_ES
dc.identifier.placeInglaterraes_ES
dc.identifier.urihttps://doi.org/10.1016/j.ejpain.2010.06.007es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/7063
dc.identifier.volumen15es_ES
dc.language.isoenges_ES
dc.publisherChichester, UK : Wileyes_ES
dc.relation15 (2) 132-138 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoEUR J PAINes_ES
dc.relation.journalEuropean journal of paines_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnalysis of Variancees_ES
dc.subject.meshAnimalses_ES
dc.subject.meshBehavior, Animales_ES
dc.subject.meshphysiologyes_ES
dc.subject.meshCerebral Cortexes_ES
dc.subject.meshphysiopathologyes_ES
dc.subject.meshHyperalgesiaes_ES
dc.subject.meshphysiopathologyes_ES
dc.subject.meshHyperalgesiaes_ES
dc.subject.meshpsychologyes_ES
dc.subject.meshInflammationes_ES
dc.subject.meshphysiopathologyes_ES
dc.subject.meshInflammationes_ES
dc.subject.meshpsychologyes_ES
dc.subject.meshMalees_ES
dc.subject.meshNeuralgiaes_ES
dc.subject.meshphysiopathology*es_ES
dc.subject.meshNeuralgiaes_ES
dc.subject.meshpsychologyes_ES
dc.subject.meshPain Measurementes_ES
dc.subject.meshPhysical Stimulationes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.titleInsular cortex lesion diminishes neuropathic and inflammatory pain-like behaviours.es_ES
dc.typearticlees_ES

Files

Collections

Artículos de revista