Spasmolytic and antinociceptive activities of ursolic acid and acacetin identified in Agastache mexicana

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dc.contributor.affiliationLaboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101, Col. Sn Lorenzo Huipulco, 14370, México, D. F. Méxicoes_ES
dc.creatorGonzález-Trujano, María Eva
dc.creatorVentura-Martínez, Rosa
dc.creatorChávez, Marco
dc.creatorDíaz-Reval, Irene
dc.creatorPellicer, Francisco
dc.creator.identificador"GOTE681027MMCNRV09">González Trujano, María Evaes_ES
dc.date.accessioned2017-06-30T03:41:29Z
dc.date.accessioned2026-03-27T14:50:52Z
dc.date.available2017-06-30T03:41:29Z
dc.date.issued2012es_ES
dc.date.published2012es_ES
dc.description.abstractotrodiomaAgastache mexicana is a plant in high demand that has long been used in Mexican folk medicine to treat anxiety, insomnia, and stomachache, among other afflictions. Ursolic acid and acacetin were isolated and identified as two possible active compounds of A. mexicana aerial parts. An antinociceptive response was demonstrated in a significant and dose-dependent manner with ursolic acid and acacetin (i. p. and p. o.) in comparison to the analgesic diclofenac by using the writhing test in mice. Moreover, acacetin also produced a significant concentration-dependent spasmolytic response with major efficacy compared to ursolic acid and papaverine by using rings from the isolated guinea pig ileum. These results provide evidence of the presence of two active constituents of Agastache mexicana reinforcing its utility as a therapy for visceral pain as used in traditional medicinees_ES
dc.description.monthMayes_ES
dc.identifier2102es_ES
dc.identifier.citationMaría Teresa Cordero Ortízes_ES
dc.identifier.doi10.1055/s-0031-1298416es_ES
dc.identifier.eissn1439-0221es_ES
dc.identifier.issn0032-0943es_ES
dc.identifier.numero8es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion793-796es_ES
dc.identifier.placeAlemaniaes_ES
dc.identifier.urihttp://doi.org/10.1055/s-0031-1298416es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/6762
dc.identifier.volumen78es_ES
dc.language.isoenges_ES
dc.publisherGeorg Thieme Verlag KG Stuttgart · New York ·es_ES
dc.relation78 (8) 793-796 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoPLANTA MEDes_ES
dc.relation.journalPlanta medicaes_ES
dc.rightsacceso cerradoes_ES
dc.subject.koAcacetines_ES
dc.subject.koAgastache mexicana (H. N. K.) Lint & Epling subsp.es_ES
dc.subject.koXolocotzianaes_ES
dc.subject.koLamiaceaees_ES
dc.subject.koAntinociceptiones_ES
dc.subject.koSpasmolytices_ES
dc.subject.koUrsolic acides_ES
dc.subject.kwAcacetines_ES
dc.subject.kwAgastache mexicana (HNK) Lint y Epling subsp.es_ES
dc.subject.kwXolocotzianaes_ES
dc.subject.kwLamiaceaees_ES
dc.subject.kwAntinocicepciónes_ES
dc.subject.kwEspasmolíticoes_ES
dc.subject.kwÁcido ursólicoes_ES
dc.subject.meshAgastache-Chemistryes_ES
dc.subject.meshAnalgesics-Isolation & purificationes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshDrug Evaluation, Preclinicales_ES
dc.subject.meshFemalees_ES
dc.subject.meshFlavonese-Isolation & purificationes_ES
dc.subject.meshFlavones-Therapeutic usees_ES
dc.subject.meshGuinea Pigses_ES
dc.subject.meshMalees_ES
dc.subject.meshMicees_ES
dc.subject.meshParasympatholytics-Isolation & purificationes_ES
dc.subject.meshTriterpenes-Isolation & purificationes_ES
dc.subject.meshTriterpenes-Therapeutic usees_ES
dc.subject.meshVisceral Pain-Drug therapyes_ES
dc.titleSpasmolytic and antinociceptive activities of ursolic acid and acacetin identified in Agastache mexicanaes_ES
dc.typearticlees_ES

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