Cognition in Euthymic Patients with Bipolar Disorder: Do Not Forget to Account for Anxiety!

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dc.contributor.affiliationClinical Epidemiology Laboratory, Clinical Research Directorate, Ramón de la Fuente Muñiz National Institute of Psychiatry, Mexico City, Mexico
dc.contributor.emailyoldin2@gmail.com
dc.creatorYoldi-Negrete, María
dc.creatorFresán, Ana
dc.creatorJiménez-Rodríguez, Laura Ivone
dc.creatorTirado-Durán, Elsa Georgina
dc.creator.identificadorhttps://orcid.org/0000-0001-8000-6434 (Yoldi-Negrete, María)
dc.creator.identificadorhttps://orcid.org/0000-0001-9160-6988 (Fresán, Ana)
dc.creator.identificadorhttps://orcid.org/0009-0002-6751-9977 (Jiménez-Rodríguez, Laura Ivone)
dc.date2024
dc.date.accessioned2026-07-16T21:06:48Z
dc.date.issued2024
dc.date.published2024
dc.descriptionDespite the high prevalence of anxiety disorders in BD and its known impact on cognitive performance, the presence and severity of anxious symptoms is not systematically evaluated in studies on cognition in BD. Our aim was to determine if attention and/or inhibition of cognitive interference in euthymic patients with type I Bipolar Disorder (BD-I) is affected by symptoms of anxiety. Patients and methods: Eighty-seven euthymic BD-I patients were included. Patients with comorbidities other than Generalized Anxiety Disorder (GAD) or Panic Disorder (PD) were excluded. State anxiety was measured with the Brief Inventory of Anxious Responses and Situations (ISRA-B). Subjective cognitive performance was evaluated with the COBRA scale, attention with the Digit-Span Forward task and inhibition of cognitive interference was assessed with the StroopTest interference score. Multiple linear regression models were used to test if anxious symptoms were associated with attention or inhibition of cognitive interference, considering other known contributors for cognitive impairment. Results: Attention was unaffected by anxiety symptoms, but the overall regression for inhibition of cognitive interference was significant: years of schooling (β=1.12, p = 0.001), cognitive complaints (β=0.44, p = 0.008), and anxiety (β=-0.21, p = 0.017) explained 15% of the interference score of the Stroop test (R2 = 0.15). Conclusion: Beyond residual affective symptoms, anxious symptoms seem to affect inhibition of cognitive interference. We recommend routine testing of anxiety when considering cognitive evaluations, especially when screening for cognitive deficits.
dc.formatPDF
dc.identifierOE37IC2025
dc.identifier.doi10.2147/NDT.S457186
dc.identifier.eissn1178-2021
dc.identifier.issn1176-6328
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeNueva Zelanda
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/205
dc.identifier.urihttps://doi.org/10.2147/NDT.S457186
dc.language.isoeng
dc.publisherDove Medical Press
dc.relation20:1181-1189
dc.relation.jnabreviadoNEUROPSYCHIATR DIS TREAT
dc.relation.journalNeuropsychiatric Disease and Treatment
dc.rightsAcceso Cerrado
dc.subject.kwStroop effect
dc.subject.kwAnxiety
dc.subject.kwAttention
dc.subject.kwBipolar-I disorder
dc.subject.kwCognitive interference
dc.subject.kwComorbid
dc.subject.kwDigit span forward
dc.titleCognition in Euthymic Patients with Bipolar Disorder: Do Not Forget to Account for Anxiety!
dc.typeArtículo

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