Progesterone Reduces Immobility in Rats Forced to Swim

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dc.contributor.affiliationLaboratorio de Neurofarmacolog??a, Instituto de Neuroetolog??a, Universidad Veracruzana, Xalapa, Veracruz, Mexicoes_ES
dc.contributor.emailcmc@bugs.invest.uv.mxes_ES
dc.creatorMartínez-Mota, Lucía
dc.creatorContreras, Carlos M.
dc.creatorSaavedra, Margarita
dc.creator.identificador"MAML700524MVZRTC06">Martínez Mota, Lucia Albaes_ES
dc.date.accessioned2017-06-30T03:43:31Z
dc.date.accessioned2026-03-27T14:51:04Z
dc.date.available2017-06-30T03:43:31Z
dc.date.issued1999es_ES
dc.date.published1999es_ES
dc.description.abstractotrodiomaAmong its behavioral actions, progesterone reduces anxiety in several species including humans; however, any antidepressant-like properties remain to be explored. Methods. In the present study, Wistar rats received injections (i.p.) of progesterone (0.20– 3.0 mg/kg) 24 and 2 h before being submitted to the forced swim, a test in which antidepressants regularly reduce immobility and exert few or no actions on locomotor activity. In order to discard the cumulative effects of progesterone and a possible effect from the repetition of the swimming test, all animals received one of several progesterone doses in a different sequence following a completely randomized experimental intrasubject design. Results. Ovariectomy did not modify immobility in the forced swim test as compared to control tests practiced before surgery. A dose of 0.80 mg/kg strongly reduced the total time of immobility in forced swim test (p,0.001), but did not modify locomotor activity. In a drug-free control test applied 1 week after the last injection of progesterone, immobility returned to the higher values observed in the control tests. Conclusions. From these results, it is concluded that progesterone may possess some antidepressant- like activity.es_ES
dc.description.monthAbres_ES
dc.identifier2178es_ES
dc.identifier.citationTomás Martínez Ibarraes_ES
dc.identifier.eissn1873-5487es_ES
dc.identifier.issn0188-4409es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.paginacion286-289es_ES
dc.identifier.placeMexico, D.F. : Instituto Mexicano del Seguro Sociales_ES
dc.identifier.urihttps://doi.org/10.1016/S0188-0128(99)00024-Xes_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/6827
dc.identifier.volumen30es_ES
dc.language.isoenges_ES
dc.relation30, 286-289 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoARCH MED RESes_ES
dc.relation.journalArchives of medical researches_ES
dc.rightsacceso cerradoes_ES
dc.subject.koAntidepressantses_ES
dc.subject.koDepressiones_ES
dc.subject.koForced swim testes_ES
dc.subject.koRates_ES
dc.subject.koProgesteronees_ES
dc.titleProgesterone Reduces Immobility in Rats Forced to Swimes_ES
dc.typearticlees_ES

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