Browsing by Author "Paz, Carlos"
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Item Amygdala kindling in totally cerebellectomized cats(1985) Paz, Carlos; Reygadas, Efrain; Fernández-Guardiola, Augusto; Unidad de Investigaciones Cerebrales, lnstituto Nacional de Neurología y Neurocirugía, Departamento de Fisiología, Facultad de Medicina U.N.A.M., Insurgentes sur No. 3877, Tlalpan, Mexico 14410, D. F.Item Amygdaloid kindling during rapid eye movement (REM) sleep in cats(1982) Calvo, José María; Alvarado, Raúl; Briones, Rafael; Paz, Carlos; Fernández-Guardiola, Augusto; Unidad de Investigaciones Cerebrales, lnstituto Nacional de Neurología Neurocírugia. lnsurgentes Sur No. 3877, Col. La Fama. Deleg. Tlalpan. 14410 México, D.F. y Facultad de Psicología, Universidad Nacional Autónoma de México, México, D.F.Item Cambios en la actividad multiunitaria del sistema cerebeloso en el gato producidos por el tiner y el delta 9-THC(1976) Fernández Guardiola, Augusto; Contreras, Carlos M.; González Estrada, Teresa; Condés, Miguel; Paz, Carlos; Jefe de la Unidad de Investigaciones Cerebrales del Instituto Nacional de Neurología y Coordinador del Area de Ciencias Biomédicas del Centro Mexicano de Estudios en Farmacodependencia. CEMEF. México, D.F.Muchos son los fármacos y sustancias que afectan la función cerebelosa; empero de entre todas, se eligió el tiner y el compuesto activo de la mariguana para su estudio. Así , pues, en el presente trabajo se describen los efectos que desarrolló una sola administración de tiner y delta 9-THC sobre la función cerebelosa, medidos a través de registros de la actividad multiunitaria de las celulas de Purkinje, corteza motora, nucleo rojo y nucleo dentado. Se analizan los resultados en cuanto a los mecanismos de acción de estas sustancias.Item Stimulation of the superior cerebellar peduncle during the development of amygdaloid kindling in rats(ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2004) Rubio, Carmen; Custodio, Verónica; Juárez, Francisco; Paz, Carlos; Inst Nacl Neurol & Neurocirug MVS, Dept Neurofisiol, Mexico City 14269, DF, Mexico; paztres@servidor.unam.mxCerebellar manipulations have been used successfully in some intractable epileptic patients, however, their intrinsic mechanisms are not fully understood. To further clarify the cerebellar participation in epilepsy, we stimulated 10 rats with 100 Hz, 20 muA at the superior cerebellar peduncle (SCP) during amygdaloid kindling. Results were compared to 10 rats with an electrode placed at the SCP without stimulation and 10 rats without electrodes at the SCP used as control. We found that SCP stimulation increased the theta and alpha rhythms at the contralateral motor cortex. Such a stimulation produced hypertonicity of the forelimbs and tremor of the head. In this condition, we found that each of the behavioral stages during amygdaloid kindling in the SCP stimulated rats was reached earlier, while the amygdaloid electrographic after discharges (ADs) were longer during the first and shorter in the final trials as compared to controls. Moreover, amygdaloid ADs recorded exclusively during the behavioral stage-5 were significantly shorter than those recorded in the control conditions. We suggest that SCP stimulation Could change the Customary electrographic and convulsive expression of amygdala kindling in such a manner as to initially facilitate the limbic seizures and impede the secondary generalized seizures. (C) 2004 Elsevier B.V. All rights reserved.