Browsing by Author "Bancalero-Flores, José Luis"

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    Is there an association between fibromyalgia and below-normal levels of urinary cortisol?
    (2008) Izquierdo-Álvarez, Silvia; Bocos-Terraz, Julia Pilar; Bancalero-Flores, José Luis; Pavón-Romero, Lenin; Serrano-Ostariz, Enrique; Alegre de Miquel, Cayetano; Department of Biochemistry (Hormonal Section), Hospital Universitario Miguel Servet, Zaragoza, Spain; sizquierdo@salud.aragon.es
    Background: Adynamia in fibromyalgia (FM) may be an expression of a functional deficit of the hypothalamic-pituitary-adrenal axis and be associated with below-normal levels of urinary cortisol. Our aim was to demonstrate that urinary cortisol was lower in patients with FM than in healthy subjects. Findings: We measured urinary cortisol levels for a sample of 47 women aged 29 to 64 years (mean age 53 years), diagnosed with FM 2–3 years previously, and compared the results with those for a control sample of 58 healthy women of a similar age. Samples of 24-hour urine were appropriately collected and levels of urinary cortisol were measured using the fluorescence polarization immunoassay method. The mean cortisol value for the women with FM was 65.40 ± 27.10 _g/L, significantly lower than the mean cortisol level for the control group, at 90.83 ± 38.17 _g/L (p < 0.001). Conclusion: Our study confirms that women with FM have significantly lower urinary cortisol levels than healthy women.