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Pallidal GABA B receptors: involvement in cortex beta dynamics and thalamic reticular nucleus activity

dc.creatorVillalobos, Nelsones_ES
dc.creatorMagdaleno-Madrigal, Victor Manueles_ES
dc.date2023
dc.date.accessioned2025-04-15T18:20:34Z
dc.date.available2025-04-15T18:20:34Z
dc.date.issued2023
dc.identifierJC89es_ES
dc.identifier.issn1880-6546
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8313
dc.identifier.urihttps://doi.org/10.1186/s12576-023-00870-8
dc.descriptionThe external globus pallidus (GP) firing rate synchronizes the basal ganglia-thalamus-cortex network controlling GABAergic output to different nuclei. In this context, two findings are significant: the activity and GABAergic transmission of the GP modulated by GABA B receptors and the presence of the GP-thalamic reticular nucleus (RTn) pathway, the functionality of which is unknown. The functional participation of GABA B receptors through this network in cortical dynamics is feasible because the RTn controls transmission between the thalamus and cortex. To analyze this hypothesis, we used single-unit recordings of RTn neurons and electroencephalograms of the motor cortex (MCx) before and after GP injection of the GABA B agonist baclofen and the antagonist saclofen in anesthetized rats. We found that GABA B agonists increase the spiking rate of the RTn and that this response decreases the spectral density of beta frequency bands in the MCx. Additionally, injections of GABA B antagonists decreased the firing activity of the RTn and reversed the effects in the power spectra of beta frequency bands in the MCx. Our results proved that the GP modulates cortical oscillation dynamics through the GP-RTn network via tonic modulation of RTn activity.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.relation73(1):14
dc.rightsAcceso Cerradoes_ES
dc.titlePallidal GABA B receptors: involvement in cortex beta dynamics and thalamic reticular nucleus activityes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationAcademia de Fisiología, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Colonia Casco de Santo Tomás, 11340, México City, México
dc.contributor.emailnvillalobosv@ipn.mx (Nelson Villalobos)
dc.relation.jnabreviadoJ PHYSIOL SCI
dc.relation.journalJournal of Physiological Sciences
dc.identifier.placeJapón
dc.date.published2023
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1880-6562
dc.identifier.doi10.1186/s12576-023-00870-8
dc.subject.kwGlobus pallidus
dc.subject.kwThalamic reticular nucleus
dc.subject.kwTonic inhibition
dc.subject.kwBeta band
dc.subject.kwDesynchronization
dc.subject.kwGABA B receptor
dc.subject.kwNetwork
dc.subject.kwDisinhibition


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