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Can psychopathy be prevented? Clinical, neuroimaging, and genetic data: an exploratory study

dc.creatorOstrosky, Feggyes_ES
dc.creatorDecety, Jeanes_ES
dc.creatorLozano, Azucenaes_ES
dc.creatorLujan, Angélicaes_ES
dc.creatorPerez, Marthaes_ES
dc.creatorMunguia, Anaes_ES
dc.creatorCastañeda, Dianelaes_ES
dc.creatorDiaz, Karlaes_ES
dc.creatorLara, Rafaeles_ES
dc.creatorSacristan, Emilioes_ES
dc.creatorBobes, Maria A.es_ES
dc.creatorBorja, Karinaes_ES
dc.creatorCamarena, Beatrizes_ES
dc.creatorHernández-Muñoz, Sandraes_ES
dc.creatorÁlvarez, Auroraes_ES
dc.creatorFranco-Bourland, Rebecca E.es_ES
dc.date2024
dc.date.accessioned2025-04-10T18:20:36Z
dc.date.available2025-04-10T18:20:36Z
dc.date.issued2024
dc.identifierJC80es_ES
dc.identifier.issn0929-7049
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8301
dc.identifier.urihttps://doi.org/10.1080/09297049.2023.2277396
dc.descriptionThe aim of the study was to explore the relationship among brain functional activations elicited by an emotional paradigm, clinical scores (PTSD, anxiety, and depression), psychopathic traits, and genetic characteristics (5-HTTLPR) in a group of severely maltreated children compared to a healthy control group before and after the implementation of a Trauma Focused-Cognitive Behavioral Therapy. The final sample consisted of an experimental group of 14 maltreated children (mean age = 8.77 years old, S.D. = 1.83) recruited from a non-governmental shelter in Mexico City for children who had experienced child abuse and a control group of 10 children from the general population (mean age = 9.57 years old, S.D. = 1.91). Both groups were matched according to age and gender and were assessed before and after the implementation of the aforementioned therapy by means of clinical scales and an emotional paradigm that elicited brain activations which were recorded through functional magnetic resonance imaging. Genotyping of the 5-HTTLPR polymorphism was made at first assessment. A region of interest analysis showed amygdala hyperactivation during exposure to fear and anger stimuli in the maltreated children before treatment. Following therapy, a decrease in brain activity as well as a decrease in clinical symptoms were also observed. 5-HTTLPR polymorphism did not show any effect on the severity of clinical symptoms in maltreated children. Trauma-Focused Behavioral Therapy may help reorganize the brain's processing of emotional stimuli. These observations reveal the importance of an early intervention when the mechanisms of neuroplasticity may be still recruited.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherRoutledgees_ES
dc.relation30(6):861-881
dc.rightsAcceso Cerradoes_ES
dc.titleCan psychopathy be prevented? Clinical, neuroimaging, and genetic data: an exploratory studyes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationFacultad de Psicología, Universidad Nacional Autónoma de México, Ciudad de México, México
dc.contributor.emailfeggyostrosky@gmail.com (Feggy Ostrosky)
dc.relation.jnabreviadoCHILD NEUROPSYCHOL
dc.relation.journalChild Neuropsychology
dc.identifier.placeInglaterra
dc.date.published2024
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1744-4136
dc.identifier.doi10.1080/09297049.2023.2277396
dc.subject.kwChildhood maltreatment
dc.subject.kwNeurodevelopmental psychopathy
dc.subject.kwPost-traumatic stress disorder
dc.subject.kwfMRl
dc.subject.kwBrain reorganization


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