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Therapeutic treatment with fluoxetine using the chronic unpredictable stress model induces changes in neurotransmitters and circulating miRNAs in extracellular vesicles

dc.creatorEstévez-Cabrera, M. Maetzies_ES
dc.creatorSánchez-Muñoz, Faustoes_ES
dc.creatorPérez-Sánchez, Gilbertoes_ES
dc.creatorPavón, Lenines_ES
dc.creatorHernández-Díazcouder, Adrianes_ES
dc.creatorCórtes Altamirano, J. Luises_ES
dc.creatorSoria-Fregoso, C.es_ES
dc.creatorAlfaro-Rodríguez, Alfonsoes_ES
dc.creatorBonilla-Jaime, Herlindaes_ES
dc.date2023
dc.date.accessioned2025-04-08T16:54:40Z
dc.date.available2025-04-08T16:54:40Z
dc.date.issued2023
dc.identifierJC77es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8296
dc.identifier.urihttps://doi.org/10.1016/j.heliyon.2023.e13442
dc.descriptionThe most widely prescribed antidepressant, fluoxetine (FLX), is known for its antioxidant and anti-inflammatory effects when administered post-stress. Few studies have evaluated the effects of FLX treatment when chronic stress has induced deleterious effects in patients. Our objective was to evaluate FLX treatment (20 mg/kg/day, i.v.) once these effects are manifested, and the drug's relation to extracellular circulating microRNAs associated with inflammation, a hedonic response (sucrose intake), the forced swim test (FST), and corticosterone levels (CORT) and monoamine concentrations in limbic areas. A group of Wistar rats was divided into groups: Control; FLX; CUMS (for six weeks of exposure to chronic, unpredictable mild stress); and CUMS + FLX, a mixed group. After CUMS, the rats performed the FST, and serum levels of CORT and six microRNAs (miR-16, -21, -144, -155, -146a, -223) were analyzed, as were levels of dopamine, noradrenaline, and serotonin in the prefrontal cortex, hippocampus, and hypothalamus. CUMS reduced body weight, sucrose intake, and hippocampal noradrenaline levels, but increased CORT, immobility behavior on the FST, dopamine concentrations in the prefrontal cortex, and all miRNAs except miR-146a expression. Administering FLX during CUMS reduced CORT levels and immobility behavior on the FST and increased the expression of miR-16, -21, -146a, -223, and dopamine. FLX protects against the deleterious effects of stress by reducing CORT and has an antidepressant effect on the FST, with minimally-modified neurotransmitter levels. FLX increased the expression of miRNAs as part of the antidepressant effect. It also regulates both neuroinflammation and serotoninergic neurotransmission through miRNAs, such as the miR-16.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation9(2):e13442
dc.rightsAcceso Cerradoes_ES
dc.titleTherapeutic treatment with fluoxetine using the chronic unpredictable stress model induces changes in neurotransmitters and circulating miRNAs in extracellular vesicleses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDoctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, UAM, Av. San Rafael Atlixco 186, Leyes de Reforma, C.P. 09340, Ciudad de México, Mexico
dc.contributor.emailbjh@xanum.uam.mx (H. Bonilla-Jaime)
dc.relation.jnabreviadoHELIYON
dc.relation.journalHeliyon
dc.identifier.placeInglaterra
dc.date.published2023
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn2405-8440
dc.identifier.doi10.1016/j.heliyon.2023.e13442
dc.subject.kwSerotonin
dc.subject.kwChronic unpredictable mild stress
dc.subject.kwCorticosterone
dc.subject.kwmiRNAs
dc.subject.kwFluoxetine
dc.subject.kwNeurotransmitters


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