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The endocrine disruptor DE-79 alters oxytocinergic transmission and sexual behavior expression in male rats

dc.creatorGarduño-Gutiérrez, Renées_ES
dc.creatorRodríguez-Manzo, Gabrielaes_ES
dc.creatorVelázquez-Alvarado, Alejandroes_ES
dc.creatorMiller-Pérez, Carolinaes_ES
dc.creatorLeón-Olea, Marthaes_ES
dc.date2023
dc.date.accessioned2025-04-04T18:15:53Z
dc.date.available2025-04-04T18:15:53Z
dc.date.issued2023
dc.identifierJC74es_ES
dc.identifier.issn0041-008X
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8293
dc.identifier.urihttps://doi.org/10.1016/j.taap.2023.116723
dc.descriptionPolybrominated diphenyl ethers (PBDEs), used as flame retardants are persistent organic pollutants exerting important health effects. PBDEs with >5 bromide substitutions were considered less harmful and therefore extensively used commercially. DE-79 was a widely used PBDE mixture of hexa-, hepta-, octa- and nona-brominated compounds that increases vasopressin (AVP) production. AVP and oxytocin (OT) are both produced in neurons of the supraoptic (SON) and paraventricular (PVN) hypothalamic nuclei projecting to the neurohypophysis and to brain regions involved in copulatory behavior. OT plays an important role in male copulation. Since DE-79 alters AVP expression in the SON and PVN, it might also modify OT content and alter male sexual behavior. We analyzed if repeated DE-79 exposure of adult male rats affected OT content and OT receptor (OTR) density in the SON, PVN, medial preoptic area (mPOA), ventral tegmental area, nucleus accumbens, and amygdala, and if male copulatory behavior was affected. We show that DE-79 exposure produces a generalized decrease in brain OT immunoreactivity, increases OTR density in all brain regions analyzed but the mPOA, and reduces the ejaculatory threshold after a first ejaculation. The documented ejaculation-induced OT release might participate in this last effect. Thus, one-week DE-79 exposure alters the OT-OTR system and modifies male rat sexual performance. Based on the literature it could be speculated that these effects are related to the putative endocrine disrupting actions of DE-79, ultimately altering brain OT levels and OTR expression that might affect copulation and other important OT-mediated brain functions.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherAcademic Presses_ES
dc.relation479:116723
dc.rightsAcceso Cerradoes_ES
dc.titleThe endocrine disruptor DE-79 alters oxytocinergic transmission and sexual behavior expression in male ratses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartamento de Farmacobiología, Cinvestav Sede Sur, Calzada de los Tenorios 235, Col. Granjas Coapa, Delegación Tlalpan, Ciudad de México C.P.14330, Mexico
dc.contributor.emailgrodrigu@cinvestav.mx (G. Rodríguez-Manzo), marthalo@imp.edu.mx (M. Leon-Olea)
dc.relation.jnabreviadoTOXICOL APPL PHARMACOL
dc.relation.journalToxicology and Applied Pharmacology
dc.identifier.placeEstados Unidos
dc.date.published2023
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1096-0333
dc.identifier.doi10.1016/j.taap.2023.116723
dc.subject.kwPBDE
dc.subject.kwEndocrine disruptor
dc.subject.kwOxytocin-oxytocin receptor system
dc.subject.kwRat male sexual behavior
dc.subject.kwEjaculatory threshold
dc.subject.kwBrain regions


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