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The effect of chronic stress on the immunogenicity and immunoprotection of the M6-TT vaccine in female mice

dc.creatorBarbosa Méndez, Susanaes_ES
dc.creatorMatus-Ortega, Mauraes_ES
dc.creatorHernández Miramontes, Ricardoes_ES
dc.creatorSalazar-Juárez, Albertoes_ES
dc.date2023
dc.date.accessioned2025-04-03T17:42:52Z
dc.date.available2025-04-03T17:42:52Z
dc.date.issued2023
dc.identifierJC73es_ES
dc.identifier.issn0031-9384
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8292
dc.identifier.urihttps://doi.org/10.1016/j.physbeh.2023.114345
dc.descriptionActive vaccination is an effective therapeutic option to reduce the reinforcing effects of opioids. Several studies showed that chronic stress affects the immune system decreasing the efficiency of some vaccines. Heroin withdrawal is a stressor and it is a stage in which the patient who abuses heroin is vulnerable to stress affects the immune response and consequently its immunoprotective capacity, then, the objective was to determine the effect of heroin-withdrawal and heroin-withdrawal plus immobilization, on the immune (immunogenicity) and protective response (behavioral response) of morphine-6-hemisuccinate-tetanus toxoid (M6-TT) vaccine in animals of two inbred mice strains with different sensitivity to drug-opioid and stress. Female BALB/c and C57Bl/6 inbred mice were immunized with the M6-TT. A solid-phase antibody-capture ELISA was used to monitor antibody titer responses after each booster dose in vaccinated animals. During the vaccination period, the animals were subjected to two different stress conditions: drug-withdrawal (DW) and immobilization (IMM). The study used tail-flick testing to evaluate the heroin-induced antinociceptive effects. Additionally, heroin-induced locomotor activity was evaluated. Stress decreased the heroin-specific antibody titer generated by the M6-TT vaccine in the two inbred mouse strains evaluated. In the two stress conditions, the antibody titer was not able to decrease the heroin-induced antinociceptive effects and locomotor activity. These findings suggest that stress decreases the production of antibodies and the immunoprotective capacity of the M6-TT vaccine. This observation is important to determine the efficacy of active vaccination as a potential therapy for patients with opioid drug use disorder, since these patients during drug-withdrawal present stress disorders, which could affect the efficacy of therapy such as active vaccination.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation271:114345
dc.rightsAcceso Cerradoes_ES
dc.titleThe effect of chronic stress on the immunogenicity and immunoprotection of the M6-TT vaccine in female micees_ES
dc.typeArtículoes_ES
dc.contributor.affiliationSubdirección de Investigaciones Clínicas, Laboratorio de Neurofarmacología Conductual, Microcirugía y Terapéutica Experimental, Instituto Nacional de Psiquiatría, México DF 14370, México
dc.contributor.emailazazel_vamp@yahoo.com.mx (A. Salazar-Juárez)
dc.relation.jnabreviadoPHYSIOL BEHAV
dc.relation.journalPhysiology & Behavior
dc.identifier.placeEstados Unidos
dc.date.published2023
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1873-507X
dc.identifier.doi10.1016/j.physbeh.2023.114345
dc.subject.kwActive vaccination
dc.subject.kwHeroin
dc.subject.kwAntibodies
dc.subject.kwM6-TT vaccine
dc.subject.kwNociception, Inbred mouse strain
dc.subject.kwLocomotor activity
dc.subject.kwStress


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