Mostrar el registro sencillo del ítem

Repetitive transcranial magnetic stimulation and fluoxetine reverse depressive-like behavior but with differential effects on Olig2-positive cells in chronically stressed mice

dc.creatorRamírez-Rodríguez, Gerardo Bernabées_ES
dc.creatorSan-Juan, David Meneseses_ES
dc.creatorRico-Becerra, Allan Irasekes_ES
dc.creatorGonzález-Olvera, Jorge Julioes_ES
dc.creatorReyes-Galindo, Verónicaes_ES
dc.date2023
dc.date.accessioned2025-04-01T19:14:22Z
dc.date.available2025-04-01T19:14:22Z
dc.date.issued2023
dc.identifierJC68es_ES
dc.identifier.issn0028-3908
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8286
dc.identifier.urihttps://doi.org/10.1016/j.neuropharm.2023.109567
dc.descriptionDepression is a mood disorder coursing with several behavioral, cellular, and neurochemical alterations. The negative impact of chronic stress may precipitate this neuropsychiatric disorder. Interestingly, downregulation of oligodendrocyte-related genes, abnormal myelin structure, and reduced numbers and density of oligodendrocytes in the limbic system have been identified in patients diagnosed with depression, but also in rodents exposed to chronic mild stress (CMS). Several reports have emphasized the importance of pharmacological or stimulation-related strategies in influencing oligodendrocytes in the hippocampal neurogenic niche. Repetitive transcranial magnetic stimulation (rTMS) has gained attention as an intervention to revert depression. Here, we hypothesized that 5 Hz (Hz) of rTMS or Fluoxetine (Flx) would revert depressive-like behaviors by influencing oligodendrocytes and revert neurogenic alterations caused by CMS in female Swiss Webster mice. Our results showed that 5 Hz rTMS or Flx revert depressive-like behavior. Only rTMS influenced oligodendrocytes by increasing the number of Olig2-positive cells in the hilus of the dentate gyrus and the prefrontal cortex. However, both strategies exerted effects on some events of the hippocampal neurogenic processes, such as cell proliferation (Ki67-positive cells), survival (CldU-positive cells), and intermediate stages (doublecortin-positive cells) along the dorsal-ventral axis of this region. Interestingly, the combination of rTMS-Flx exerted antidepressant-like effects, but the increased number of Olig2-positive cells observed in mice treated only with rTMS was canceled. However, rTMS-Flx exerted a synergistic effect by increasing the number of Ki67-positive cells. It also increased the number of CldU- and doublecortin-positive cells in the dentate gyrus. Our results demonstrate that 5 Hz rTMS has beneficial effects, as it reverted depressive-like behavior by increasing the number of Olig2-positive cells and reverting the decrement in hippocampal neurogenesis in CMS-exposed mice. Nevertheless, the effects of rTMS on other glial cells require further investigation.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherPergamon Presses_ES
dc.relation236:109567
dc.rightsAcceso Cerradoes_ES
dc.titleRepetitive transcranial magnetic stimulation and fluoxetine reverse depressive-like behavior but with differential effects on Olig2-positive cells in chronically stressed micees_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Neurogénesis, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Calzada México-Xochimilco 101, Alcaldía Tlalpan, C.P, 14370, Ciudad de México, Mexico
dc.contributor.emailgbernabe@imp.edu.mx (G.B. Ramírez-Rodríguez)
dc.relation.jnabreviadoNEUROPHARMACOLOGY
dc.relation.journalNeuropharmacology
dc.identifier.placeInglaterra
dc.date.published2023
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1873-7064
dc.identifier.doi10.1016/j.neuropharm.2023.109567
dc.subject.kwRepetitive transcranial magnetic stimulation
dc.subject.kwFluoxetine
dc.subject.kwHippocampus
dc.subject.kwDentate gyrus
dc.subject.kwPrefrontal cortex
dc.subject.kwOligodendrocytes
dc.subject.kwOlig2
dc.subject.kwAdult neurogenesis
dc.subject.kwChronic mild stress


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem