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Potential of olfactory neuroepithelial cells as a model to study schizophrenia: a focus on GPCRs (Review)

dc.creatorSánchez-Florentino, Zuly A.es_ES
dc.creatorRomero-Martínez, Bianca S.es_ES
dc.creatorFlores-Soto, Edgares_ES
dc.creatorSerrano, Héctores_ES
dc.creatorMontaño, Luis M.es_ES
dc.creatorValdés-Tovar, Marcelaes_ES
dc.creatorCalixto, Eduardoes_ES
dc.creatorAquino-Gálvez, Arnoldoes_ES
dc.creatorLópez-Riquelme, Germán O.es_ES
dc.creatorAlvarado, Ramónes_ES
dc.creatorArgueta, Jesúses_ES
dc.creatorSolís-Chagoyán, Héctores_ES
dc.creatorSommer, Bettinaes_ES
dc.date2024
dc.date.accessioned2025-03-31T18:26:36Z
dc.date.available2025-03-31T18:26:36Z
dc.date.issued2024
dc.identifierJC65es_ES
dc.identifier.issn1107-3756
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8282
dc.identifier.urihttps://doi.org/10.3892/ijmm.2023.5331
dc.descriptionSchizophrenia (SZ) is a multifactorial disorder characterized by volume reduction in gray and white matter, oxidative stress, neuroinflammation, altered neurotransmission, as well as molecular deficiencies such as punctual mutation in Disrupted‑in‑Schizophrenia 1 protein. In this regard, it is essential to understand the underlying molecular disturbances to determine the pathophysiological mechanisms of the disease. The signaling pathways activated by G protein‑coupled receptors (GPCRs) are key molecular signaling pathways altered in SZ. Convenient models need to be designed and validated to study these processes and mechanisms at the cellular level. Cultured olfactory stem cells are used to investigate neural molecular and cellular alterations related to the pathophysiology of SZ. Multipotent human olfactory stem cells are undifferentiated and express GPCRs involved in numerous physiological functions such as proliferation, differentiation and bioenergetics. The use of olfactory stem cells obtained from patients with SZ may identify alterations in GPCR signaling that underlie dysfunctional processes in both undifferentiated and specialized neurons or derived neuroglia. The present review aimed to analyze the role of GPCRs and their signaling in the pathophysiology of SZ. Culture of olfactory epithelial cells constitutes a suitable model to study SZ and other psychiatric disorders at the cellular level.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherSpandidos,es_ES
dc.relation53(1):7
dc.rightsAcceso Cerradoes_ES
dc.titlePotential of olfactory neuroepithelial cells as a model to study schizophrenia: a focus on GPCRs (Review)es_ES
dc.typeArtículoes_ES
dc.contributor.affiliationNeuropharmacology Laboratory, Clinical Research Branch, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City 14370, Mexico
dc.contributor.emailhecsolch@gmail.com (Héctor Solís‑Chagoyán) ; bsommerc@hotmail.com(Bettina Sommer)
dc.relation.jnabreviadoINT J MOL MED
dc.relation.journalInternational Journal of Molecular Medicine
dc.identifier.placeGrecia
dc.date.published2024
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1791-244X
dc.identifier.doi10.3892/ijmm.2023.5331
dc.subject.kwG protein‑coupled receptor
dc.subject.kwHuman neural stem cell
dc.subject.kwOlfactory epithelium
dc.subject.kwSchizophrenia
dc.subject.kwDopamine
dc.subject.kwGlutamate
dc.subject.kwSerotonin


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