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Pharmacological disadvantages in the spasmolytic effects by using the mixture known as "three toronjiles" in folk medicine

dc.creatorÁngeles-López, Guadalupe E.es_ES
dc.creatorHernández-Ruíz, Angélicaes_ES
dc.creatorGonzález-Trujano, Ma Evaes_ES
dc.creatorCristians, Soles_ES
dc.creatorOvalle-Magallanes, Berenicees_ES
dc.creatorVentura-Martínez, Rosaes_ES
dc.date2024
dc.date.accessioned2025-03-31T16:35:46Z
dc.date.available2025-03-31T16:35:46Z
dc.date.issued2024
dc.identifierJC64es_ES
dc.identifier.issn0378-8741
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8281
dc.identifier.urihttps://doi.org/10.1016/j.jep.2023.116978
dc.descriptionEthnopharmacology relevance: In Mexico, Agastache mexicana subsp. mexicana (PT) and subsp. xolocotziana (WT), and Dracocephalum moldavica (BT), are used together as the "three toronjiles" to treat gastrointestinal spasms. Aim of study: To evaluate if the spasmolytic activity of these three medicinal species is better in combination or in an individual manner. Materials and methods: Spasmolytic effect of PT, WT and BT alone or combinate were evaluated in rings of the guinea-pig ileum contracted with potassium chloride (KCl), electrical field stimulation (EFS), or acetylcholine (ACh). Chemical analysis by thin layer and ultra-high pressure liquid chromatography of the aqueous extracts of each species were done for their comparison, and their acute toxicity were determined in mice. Results: PT and WT diminished in a dose-dependent manner the contractions induced by KCl, EFS, and ACh. Whereas BT did not altered contractions in any experimental protocol. A combination of the PT (EC50) and WT (EC50) diminished the contractions induced by KCl or EFS. Interestingly, the addition of BT extract (10 μg/ml) to the combination (PT EC30 + WT EC30) blocked the inhibitory effect produced on the contracted tissue in the presence of KCl, EFS, or ACh. Moreover, addition of BT extract (100 μg/ml) to the same combination blocked the inhibitory effect on the pre-contracted tissue only in the presence of EFS. None of the aqueous extracts produced toxicity in its individual administration in mice. Chemical analysis demonstrated similarities between PT and WT, but differences with BT. Conclusions: The results of this study confirmed that either combined or by themselves aqueous extracts of PT and WT produced a spasmolytic action on guinea pig ileum, suggesting that this combination of medicinal plants could relieve gastrointestinal diseases in human, but when BT aqueous extract is added to those obtained with PT and WT, the spasmolytic activity diminished or even was blocked. Our results give evidence that mixture of several plants might produce disadvantages in the medicinal properties of their individual activity.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation318(Pt B):116978
dc.rightsAcceso Cerradoes_ES
dc.titlePharmacological disadvantages in the spasmolytic effects by using the mixture known as "three toronjiles" in folk medicinees_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico
dc.contributor.emailgeangeles@yahoo.com.mx (G.E. Ángeles-López), angelicahernandezcel@gmail.com (A. Hernández-Ruíz), evag@imp.edu.mx (M.E. González-Trujano), sol.cristians@ib.unam.mx (S. Cristians), ovalle.magallanes@quimica.unam.mx (B. Ovalle-Magallanes), rventuram7@hotmail.com (R. Ventura-Martínez)
dc.relation.jnabreviadoJ ETHNOPHARMACOL
dc.relation.journalJournal of Ethnopharmacology
dc.identifier.placeIrlanda
dc.date.published2024
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1872-7573
dc.identifier.eissn1872-7573
dc.identifier.doi10.1016/j.jep.2023.116978
dc.subject.kwAgastache mexicana subsp. mexicana
dc.subject.kwA.gastache mexicana subsp. xolocotziana
dc.subject.kwDracocephalum moldavica
dc.subject.kw“Three toronjiles”
dc.subject.kwSpasmolytic effect


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