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Imipramine Administration in Brucella abortus 2308-Infected Mice Restores Hippocampal Serotonin Levels, Muscle Strength, and Mood, and Decreases Spleen CFU Count

dc.creatorMaldonado-García, José Luises_ES
dc.creatorPérez-Sánchez, Gilbertoes_ES
dc.creatorBecerril-Villanueva, Enriquees_ES
dc.creatorAlvarez-Herrera, Samanthaes_ES
dc.creatorPavón, Lenines_ES
dc.creatorSánchez-Torres, Luviaes_ES
dc.creatorGutiérrez-Ospina, Gabrieles_ES
dc.creatorGirón-Pérez, Manuel Ivánes_ES
dc.creatorDamian-Morales, Gabrielaes_ES
dc.creatorMaldonado-Tapia, Jesús Octavioes_ES
dc.creatorLópez-Santiago, Rubénes_ES
dc.creatorMoreno-Lafont, Martha C.es_ES
dc.date2023
dc.date.accessioned2025-03-27T16:47:02Z
dc.date.available2025-03-27T16:47:02Z
dc.date.issued2023
dc.identifierJC59es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8276
dc.identifier.urihttps://doi.org/10.3390/ph16111525
dc.descriptionBrucellosis infection causes non-specific symptoms such as fever, chills, sweating, headaches, myalgia, arthralgia, anorexia, fatigue, and mood disorders. In mouse models, it has been associated with increased levels of IL-6, TNF-α, and IFN-γ, a decrease in serotonin and dopamine levels within the hippocampus, induced loss of muscle strength and equilibrium, and increased anxiety and hopelessness. Imipramine (ImiP), a tricyclic antidepressant, is used to alleviate neuropathic pain. This study evaluated the effects of ImiP on Balb/c mice infected with Brucella abortus 2308 (Ba) at 14- and 28-days post-infection. Serum levels of six cytokines (IFN-γ, IL-6, TNF-α, IL-12, MCP-1. and IL-10) were assessed by FACS, while the number of bacteria in the spleen was measured via CFU. Serotonin levels in the hippocampus were analyzed via HPLC, and behavioral tests were conducted to assess strength, equilibrium, and mood. Our results showed that mice infected with Brucella abortus 2308 and treated with ImiP for six days (Im6Ba14) had significantly different outcomes compared to infected mice (Ba14) at day 14 post-infection. The mood was enhanced in the forced swimming test (FST) (p < 0.01), tail suspension test (TST) (p < 0.0001), and open-field test (p < 0.0001). Additionally, there was an increase in serotonin levels in the hippocampus (p < 0.001). Furthermore, there was an improvement in equilibrium (p < 0.0001) and muscle strength (p < 0.01). Lastly, there was a decrease in IL-6 levels (p < 0.05) and CFU count in the spleen (p < 0.0001). At 28 days, infected mice that received ImiP for 20 days (Im20Ba28) showed preservation of positive effects compared to infected mice (Ba28). These effects include the following: (1) improved FST (p < 0.0001) and TST (p < 0.0001); (2) better equilibrium (p < 0.0001) and muscle strength (p < 0.0001); (3) decreased IL-6 levels (p < 0.05); and (4) reduced CFU count in the spleen (p < 0.0001). These findings suggest the potential for ImiP to be used as an adjuvant treatment for the symptoms of brucellosis, which requires future studies.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation16(11):1525
dc.rightsAcceso Cerradoes_ES
dc.titleImipramine Administration in Brucella abortus 2308-Infected Mice Restores Hippocampal Serotonin Levels, Muscle Strength, and Mood, and Decreases Spleen CFU Countes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Psicoinmunología, Dirección de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City 14370, Mexico
dc.contributor.emaillkuriaki@inprf.gob.mx (L.P.); mlafont@ipn.mx (M.C.M.-L.)
dc.relation.jnabreviadoPHARMACEUTICALS (BASEL)
dc.relation.journalPharmaceuticals
dc.identifier.placeSuiza
dc.date.published2023
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1424-8247
dc.identifier.doi10.3390/ph16111525
dc.subject.kwBrucellosis
dc.subject.kwImipramine
dc.subject.kwSerotonin
dc.subject.kwStrength test
dc.subject.kwIL-6
dc.subject.kwPhysical performance


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