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Examining the role of histaminergic, orexinergic, and cannabinergic systems in redox regulation in gastric adenocarcinoma

dc.creatorTorres-Román, Ana Lauraes_ES
dc.creatorRodríguez-Flores, Karla Luceroes_ES
dc.creatorHernández-Mora, Víctor Manueles_ES
dc.creatorRuiz-García, Erikaes_ES
dc.creatorProspero-García, Oscares_ES
dc.creatorGuijosa, Albertoes_ES
dc.creatorMolina, Anayansies_ES
dc.creatorMorales-Mulia, Marcelaes_ES
dc.creatorAschner, Michaeles_ES
dc.creatorSantamaría, Abeles_ES
dc.creatorOrtega-Gómez, Alettees_ES
dc.date2023
dc.date.accessioned2025-03-25T19:34:42Z
dc.date.available2025-03-25T19:34:42Z
dc.date.issued2023
dc.identifierJC58es_ES
dc.identifier.issn1389-5575
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8272
dc.identifier.urihttps://doi.org/10.2174/1389557523666230221104504
dc.descriptionHistaminergic, orexinergic, and cannabinoid systems play a role in both physiologic and oncogenic mechanisms in digestive tissues. These three systems are important mediators of tumor transformation, as they are associated with redox alterations, which are key aspects in oncological disorders. The three systems are known to promote alterations in the gastric epithelium through intracellular signaling pathways, such as oxidative phosphorylation, mitochondrial dysfunction, and increased Akt, which might promote tumorigenesis. Histamine promotes cell transformation through redox-mediated alterations in the cell cycle, DNA repair, and immunological response. The increase in histamine and oxidative stress generates angiogenic and metastatic signals through the VEGF receptor and H2R-cAMP-PKA pathway. Immunosuppression in the presence of histamine and ROS is linked to a decrease in dendritic and myeloid cells in gastric tissue. These effects are counteracted by histamine receptor antagonists, such as cimetidine. Regarding orexins, overexpression of the Orexin 1 Receptor (OX1R) induces tumor regression through the activation of MAPK-dependent caspases and src-tyrosine. OX1R agonists are candidates for the treatment of gastric cancer by stimulating apoptosis and adhesive interactions. Lastly, cannabinoid type 2 (CB2) receptor agonists increase ROS, leading to the activation of apoptotic pathways. In contrast, cannabinoid type 1 (CB1) receptor agonists decrease ROS formation and inflammation in gastric tumors exposed to cisplatin. Overall, the repercussion of ROS modulation through these three systems on tumor activity in gastric cancer depends on intracellular and/or nuclear signals associated with proliferation, metastasis, angiogenesis, and cell death. Here, we review the role of these modulatory systems and redox alterations in gastric cancer.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherBentham Science Publisherses_ES
dc.relation23(18):1806-1817
dc.rightsAcceso Cerradoes_ES
dc.titleExamining the role of histaminergic, orexinergic, and cannabinergic systems in redox regulation in gastric adenocarcinomaes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Medicina Traslacional, Instituto Nacional de Cancerología, S.S.A., Mexico City, 14080, Mexico
dc.relation.jnabreviadoMINI REV MED CHEM
dc.relation.journalMini Reviews in Medicinal Chemistry
dc.identifier.placePaíses Bajos
dc.date.published2023
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1875-5607
dc.identifier.doi10.2174/1389557523666230221104504
dc.subject.kwOrexins
dc.subject.kwCannabinoids
dc.subject.kwGastric cancer
dc.subject.kwHistamine
dc.subject.kwRedox activity
dc.subject.kwTherapeutic modulation


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