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Dissociation of arousal index between REM and NREM sleep in elderly adults with cognitive impairment, no dementia: a pilot study

dc.creatorRosales-Lagarde, Alejandraes_ES
dc.creatorCubero-Rego, Lourdeses_ES
dc.creatorMenéndez-Conde, Federicoes_ES
dc.creatorRodríguez-Torres, Erika E.es_ES
dc.creatorItzá-Ortiz, Benjamínes_ES
dc.creatorMartínez-Alcalá, Claudiaes_ES
dc.creatorVázquez-Tagle, Génesises_ES
dc.creatorVázquez-Mendoza, Enriquees_ES
dc.creatorEraña Díaz, Marta L.es_ES
dc.date2023
dc.date.accessioned2025-03-25T16:22:53Z
dc.date.available2025-03-25T16:22:53Z
dc.date.issued2023
dc.identifierJC55es_ES
dc.identifier.issn1387-2877
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8267
dc.identifier.urihttp://doi.org/10.3233/JAD-230101
dc.descriptionBackground: Sleep disruption in elderly has been associated with an increased risk of cognitive impairment and its transition into Alzheimer's disease (AD). High arousal indices (AIs) during sleep may serve as an early-stage biomarker of cognitive impairment non-dementia (CIND). Objective: Using full-night polysomnography (PSG), we investigated whether CIND is related to different AIs between NREM and REM sleep stages. Methods: Fourteen older adults voluntarily participated in this population-based study that included Mini-Mental State Examination, Neuropsi battery, Katz Index of Independence in Activities of Daily Living, and single-night PSG. Subjects were divided into two groups (n = 7 each) according to their results in Neuropsi memory and attention subtests: cognitively unimpaired (CU), with normal results; and CIND, with -2.5 standard deviations in memory and/or attention subtests. AIs per hour of sleep during N1, N2, N3, and REM stages were obtained and correlated with Neuropsi total score (NTS). Results: AI (REM) was significantly higher in CU group than in CIND group. For the total sample, a positive correlation between AI (REM) and NTS was found (r = 0.68, p = 0.006), which remained significant when controlling for the effect of age and education. In CIND group, the AI (N2) was significantly higher than the AI (REM) . Conclusion: In CIND older adults, this attenuation of normal arousal mechanisms in REM sleep are dissociated from the relative excess of arousals observed in stage N2. We propose as probable etiology an early hypoactivity at the locus coeruleus noradrenergic system, associated to its early pathological damage, present in the AD continuum.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherSAGE Publicationses_ES
dc.relation95(2):477-491
dc.rightsAcceso Cerradoes_ES
dc.titleDissociation of arousal index between REM and NREM sleep in elderly adults with cognitive impairment, no dementia: a pilot studyes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationCONACyT Chairs, National Council of Science and Technology, Mexico
dc.contributor.emaillourdes.cubero@gmail.com (Lourdes Cubero-Rego)
dc.relation.jnabreviadoJ ALZHEIMERS DIS
dc.relation.journalJournal of Alzheimer's Disease
dc.identifier.placeEstados Unidos
dc.date.published2023
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1875-8908
dc.identifier.doi10.3233/JAD-230101
dc.subject.kwAlzheimer’s disease
dc.subject.kwArousals
dc.subject.kwLocus coeruleus
dc.subject.kwMild cognitive impairment
dc.subject.kwNeuropsychological testing
dc.subject.kwPolysomnography
dc.subject.kwREM sleep


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