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Anxiolytic-like effects and quantitative EEG profile of palmitone induces responses like buspirone rather than diazepam as clinical drugs

dc.creatorOnofre-Campos, Daniela
dc.creatorGonzález-Trujano, María Eva
dc.creatorMoreno-Pérez, Gabriel Fernando
dc.creatorNarváez-González, Fernando
dc.creatorGonzález-Gómez, José David
dc.creatorVillasana-Salazar, Benjamín
dc.creatorMartínez-Vargas, David
dc.date2023
dc.date.accessioned2025-03-20T18:41:22Z
dc.date.available2025-03-20T18:41:22Z
dc.date.issued2023
dc.identifierJC49es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8261
dc.identifier.urihttps://doi.org/10.3390/molecules28093680
dc.descriptionAnxiety is a mental disorder with a growing worldwide incidence due to the SARS-CoV-2 virus pandemic. Pharmacological therapy includes drugs such as benzodiazepines (BDZs) or azapirones like buspirone (BUSP) or analogs, which unfortunately produce severe adverse effects or no immediate response, respectively. Medicinal plants or their bioactive metabolites are a shared global alternative to treat anxiety. Palmitone is one active compound isolated from Annona species due to its tranquilizing activity. However, its influence on neural activity and possible mechanism of action are unknown. In this study, an electroencephalographic (EEG) spectral power analysis was used to corroborate its depressant activity in comparison with the anxiolytic-like effects of reference drugs such as diazepam (DZP, 1 mg/kg) and BUSP (4 mg/kg) or 8-OH-DPAT (1 mg/kg), alone or in the presence of the GABAA (picrotoxin, PTX, 1 mg/kg) or serotonin 5-HT1A receptor antagonists (WAY100634, WAY, 1 mg/kg). The anxiolytic-like activity was assayed using the behavioral response of mice employing open-field, hole-board, and plus-maze tests. EEG activity was registered in both the frontal and parietal cortex, performing a 10 min baseline and 30 min recording after the treatments. As a result, anxiety-like behavior was significantly decreased in mice administered with palmitone, DZP, BUSP, or 8-OH-DPAT. The effect of palmitone was equivalent to that produced by 5-HT1A receptor agonists but 50% less effective than DZP. The presence of PTX and WAY prevented the anxiolytic-like response of DZP and 8-OH-DPAT, respectively. Whereas only the antagonist of the 5-HT1A receptor (WAY) inhibited the palmitone effects. Palmitone and BUSP exhibited similar changes in the relative power bands after the spectral power analysis. This response was different to the changes induced by DZP. In conclusion, brain electrical activity was associated with the anxiolytic-like effects of palmitone implying a serotoninergic rather than a GABAergic mechanism of action.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation28(9):3680
dc.rightsAcceso Cerradoes_ES
dc.titleAnxiolytic-like effects and quantitative EEG profile of palmitone induces responses like buspirone rather than diazepam as clinical drugses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Ciudad de México 14370, Mexico
dc.contributor.emailevag@imp.edu.mx (M.E.G.-T.); davmv2@gmail.com (D.M.-V.)
dc.relation.jnabreviadoMOLECULES
dc.relation.journalMolecules
dc.identifier.placeSuiza
dc.date.published2023
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1420-3049
dc.identifier.doi10.3390/molecules28093680
dc.subject.kwAnxiety
dc.subject.kwDelta band
dc.subject.kwElectroencephalography
dc.subject.kwFatty acids
dc.subject.kw16-hentriacontanone
dc.subject.kwPalmitone


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