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Antinociceptive and antiedema efects produced in rats by Brassica oleracea var. italica sprouts involving sulforaphane

dc.creatorGuadarrama-Enríquez, Omares_ES
dc.creatorMoreno-Pérez, Gabriel Fernandoes_ES
dc.creatorGonzález-Trujano, María Evaes_ES
dc.creatorÁngeles-López, Guadalupe Estheres_ES
dc.creatorVentura-Martínez, Rosaes_ES
dc.creatorDíaz-Reval, Irenees_ES
dc.creatorCano-Martínez, Agustinaes_ES
dc.creatorPellicer, Franciscoes_ES
dc.creatorBaenas, Nieveses_ES
dc.creatorMoreno, Diego A.es_ES
dc.creatorGarcía-Viguera, Cristinaes_ES
dc.date2023
dc.date.accessioned2025-03-20T18:13:17Z
dc.date.available2025-03-20T18:13:17Z
dc.date.issued2023
dc.identifierJC48es_ES
dc.identifier.issn0925-4692
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8260
dc.identifier.urihttps://doi.org/10.1007/s10787-023-01326-6
dc.descriptionNatural products are recognized as potential analgesics since many of them are part of modern medicine to relieve pain without serious adverse effects. The aim of this study was to investigate the antinociceptive and anti-inflammatory activities of an aqueous extract of Brassica oleracea var. italica sprouts (AEBS) and one of its main reported bioactive metabolites sulforaphane (SFN). Antinociceptive activity of the AEBS (30, 100, and 300 mg/kg, i.p. or 1000 and 2000 mg/kg, p.o.) and SFN (0.1 mg/kg, i.p.) was evaluated in the plantar test in rats to reinforce its analgesic-like activity at central level using the reference drug tramadol (TR, 50 mg/kg, i.p.). The anti-inflammatory-like response was determined in the carrageenan-induced oedema at the same dosages for comparison with ketorolac (KET, 20 mg/kg, i.p.) or indomethacin (INDO, 20 mg/kg, p.o.). A histological analysis of the swollen paw was included to complement the anti-inflammatory response. Additionally, acute toxicity observed in clinical analgesics as the most common adverse effects, such as sedation and/or gastric damage, was also explored. As a result, central and peripheral action of the AEBS was confirmed using enteral and parenteral administration, in which significant reduction of the nociceptive and inflammatory responses resembled the effects of TR, KET, or INDO, respectively, involving the presence of SFN. No adverse or toxic effects were observed in the presence of the AEBS or SFN. In conclusion, this study supports that Brassica oleracea var. italica sprouts are a potential source of antinociceptive natural products such as SFN for therapy of pain alone and associated to an inflammation condition.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherBirkhäuseres_ES
dc.relation31(6):3217-3226
dc.rightsAcceso Cerradoes_ES
dc.titleAntinociceptive and antiedema efects produced in rats by Brassica oleracea var. italica sprouts involving sulforaphanees_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Neurofarmacología de Productos Naturales. Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría "Ramón de La Fuente Muñiz", Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, 14370, Tlalpan. C.P, Ciudad de Mexico, México
dc.contributor.emailevag@imp.edu.mx (María Eva González-Trujano) ; cgviguera@cebas.csic.es (Cristina García-Viguera)
dc.relation.jnabreviadoINFLAMMOPHARMACOLOGY
dc.relation.journalInflammopharmacology
dc.identifier.placeSuiza
dc.date.published2023
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1568-5608
dc.subject.kwAnalgesics
dc.subject.kwBroccoli
dc.subject.kwIsothiocyanate
dc.subject.kwOpioids
dc.subject.kwSulforaphane


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