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Modulation of vagal activity may help reduce neurodevelopmental damage in the offspring of mothers with pre-eclampsia

dc.creatorAbarca-Castro, Eric Alonsoes_ES
dc.creatorTalavera-Peña, Ana Karenes_ES
dc.creatorReyes-Lagos, José Javieres_ES
dc.creatorBecerril-Villanueva, Enriquees_ES
dc.creatorPérez-Sanchez, Gilbertoes_ES
dc.creatorde la Peña, Francisco R.es_ES
dc.creatorMaldonado-García, José Luises_ES
dc.creatorPavón, Lenines_ES
dc.date2023
dc.date.accessioned2025-03-13T16:54:39Z
dc.date.available2025-03-13T16:54:39Z
dc.date.issued2023
dc.identifierJC35es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8245
dc.identifier.urihttps://doi.org/10.3389/fimmu.2023.1280334
dc.descriptionMaternal Immune Activation (MIA) has been linked to the pathogenesis of pre-eclampsia and adverse neurodevelopmental outcomes in the offspring, such as cognitive deficits, behavioral abnormalities, and mental disorders. Pre-eclampsia is associated with an activation of the immune system characterized by persistently elevated levels of proinflammatory cytokines, as well as a decrease in immunoregulatory factors. The Cholinergic Anti-inflammatory Pathway (CAP) may play a relevant role in regulating the maternal inflammatory response during pre-eclampsia and protecting the developing fetus from inflammation-induced damage. Dysregulation in the CAP has been associated with the clinical evolution of pre-eclampsia. Some studies suggest that therapeutic stimulation of this pathway may improve maternal and fetal outcomes in preclinical models of pre-eclampsia. Modulation of vagal activity influences the CAP, improving maternal hemodynamics, limiting the inflammatory response, and promoting the growth of new neurons, which enhances synaptic plasticity and improves fetal neurodevelopment. Therefore, we postulate that modulation of vagal activity may improve maternal and fetal outcomes in pre-eclampsia by targeting underlying immune dysregulation and promoting better fetal neurodevelopment. In this perspective, we explore the clinical and experimental evidence of electrical, pharmacological, physical, and biological stimulation mechanisms capable of inducing therapeutical CAP, which may be applied in pre-eclampsia to improve the mother's and offspring's quality of life.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherFrontiers Research Foundationes_ES
dc.relation14:1280334
dc.rightsAcceso Cerradoes_ES
dc.titleModulation of vagal activity may help reduce neurodevelopmental damage in the offspring of mothers with pre-eclampsiaes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Lerma (UAM-L), Lerma, Mexico
dc.contributor.emaila.talavera@correo.ler.uam.mx (Ana Karen Talavera-Peña); lkuriaki@inprf.gob.mx (Lenin Pavón)
dc.relation.jnabreviadoFRONT IMMUNOL
dc.relation.journalFrontiers in Immunology
dc.identifier.placeSuiza
dc.date.published2023
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1664-3224
dc.identifier.doi10.3389/fimmu.2023.1280334
dc.subject.kwMaternal immune activation
dc.subject.kwPre-eclampsia
dc.subject.kwCholinergic anti-inflammatory pathway
dc.subject.kwNeurodevelopmental outcomes
dc.subject.kwVagus nerve stimulation
dc.subject.kwQuality of life


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