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Treatment-Resistant Depression in America Latina study: one-year follow-up of treatment resistant depression patients under standard of care reveals insights on quality of life, disability, work impairment, and depressive symptoms

dc.creatorRecco, Kelenes_ES
dc.creatorGarcia Bonetto, Gerardoes_ES
dc.creatorLupo, Christianes_ES
dc.creatorNardi, Antonio E.es_ES
dc.creatorMorales, Arnulfoes_ES
dc.creatorBecerra-Palars, Claudiaes_ES
dc.creatorPerocco, Sergioes_ES
dc.creatorPfau, Alannaes_ES
dc.date2023
dc.date.accessioned2025-02-25T20:33:24Z
dc.date.available2025-02-25T20:33:24Z
dc.date.issued2023
dc.identifierJC15es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8229
dc.identifier.urihttps://doi.org/10.3389/fpsyt.2023.1221746
dc.descriptionIntroduction: Depressive Disorders are on the rise worldwide. This is also the case in Latin America (LatAm). Treatment-Resistant Depressive Disorder (TRD) poses additional burden to patients with depression. Impacts quality of life (QoL) and other dimensions, and standard of care (SOC) is insufficient to achieve the desired clinical outcomes. Evidence from LatAm is, however, lacking. The present study was devised as a 1-year follow-up of the SOC in TRD patients in LatAm to explore the burden of TRD. Methods: This was an observational, multinational, longitudinal study. Patients with clinical diagnosis of TRD in LatAm were included in a 1-year follow-up with SOC. Beyond the Sociodemographic characterization, outcome measures were QoL (EQ-5D-5L), disability (Sheehan Disability Scale - SDS), work productivity (Work Productivity and Activity Incapacity Questionnaire: depression - WPAI:D) and depression severity (Patient Health Questionnaire-PHQ9). Patients were assessed every 3-months and comparison was performed based on change from baseline to each visit and end of study (EOS - 12 months). Results: Patients averaged 48 (± 13.12) years, mostly female (80.9%) and married/consensual union (42.5%) or single patients (34.4%). Despite the SOC treatment, three-quarters of the patients remained symptomatic at EOS, regardless of the significant longitudinal decrease (p ≤ 0.001). Similar trends were found for disability (p ≤ 0.001) -82.2% of the patients reporting work/school disruption at EOS-, percentage of work (34%) and activity impairment (40%) at EOS (p ≤ 0.001) and only 29.2% of patients with depressive severity "none" at EOS (p ≤ 0.001). The results portray the need to improve clinical outcomes in this complex and burdensome disease in LatAm. Discussion: Here we show that the burden of TRD remains significant in essential dimensions of everyday life at EOS underlining the need for better therapeutic solutions. The improvements in most patients do not provide the desired outcome of return to the state before the condition. Further research should focus on identifying which treatments provide better outcomes in a real-world context.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherFrontiers Research Foundationes_ES
dc.relation14:1221746
dc.rightsAcceso Cerradoes_ES
dc.titleTreatment-Resistant Depression in America Latina study: one-year follow-up of treatment resistant depression patients under standard of care reveals insights on quality of life, disability, work impairment, and depressive symptomses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationInstituto de Neurociências Dr João Quevedo, Criciúma, Santa Catarina, Brazil
dc.contributor.emailAPfau7@ITS.JNJ.com (Alanna Pfau)
dc.relation.jnabreviadoFRONT PSYCHIATRY
dc.relation.journalFrontiers in Psychiatry
dc.identifier.placeSuiza
dc.date.published2023
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1664-0640
dc.identifier.doi10.3389/fpsyt.2023.1221746
dc.subject.kwTreatment-resistant depressive disorder
dc.subject.kwLongitudinal study
dc.subject.kwQuality of life
dc.subject.kwStandard of care
dc.subject.kwPatient reported outcome measures
dc.subject.kwLatin America


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