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Protective effect of Tilia americana var. mexicana against kainic acid-induced damage in brain, liver, and kidney: behavioral and biochemical changes

dc.creatorCoballase-Urrutia, Elviaes_ES
dc.creatorCárdenas-Rodríguez, Noemíes_ES
dc.creatorCarmona-Aparicio, Lilianaes_ES
dc.creatorSánchez-Valle, Vicentees_ES
dc.creatorRivera-Espinosa, Lilianaes_ES
dc.creatorPedraza-Chaverri, Josées_ES
dc.creatorMontesinos-Correa, Hortenciaes_ES
dc.creatorBello-Robles, Edithes_ES
dc.creatorSampieri, Aristides IIIes_ES
dc.creatorMartínez-Vargas, Davides_ES
dc.creatorGranados-Rojas, Leticiaes_ES
dc.creatorGonzález-Trujano, María Evaes_ES
dc.date2022
dc.date.accessioned2025-01-08T17:34:21Z
dc.date.available2025-01-08T17:34:21Z
dc.date.issued2022
dc.identifierJC38NC22es_ES
dc.identifier.issn1735-0328
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8192
dc.identifier.urihttps://doi.org/10.5812/ijpr-126914
dc.descriptionTiliaamericana var. mexicana (Tilia) possesses anticonvulsant, antioxidant, neuroprotective, and hepatoprotective activities. The spectrum of anticonvulsant activity in status epilepticus models has not been sufficiently explored. We evaluated the effects of ethyl acetate (EAc), and methanol (ME) extracts on kainic acid (KA)-induced seizures by measuring rats'behavior (severity and latency) and lipoperoxidation in different brain areas (cerebellum, brain hemispheres, cortex, and medulla), kidneys, and liver. Male Wistar rats were administered KA (10 mg/kg, i.p.) after three days of pretreatment with Tilia extract (100 mg/kg). The EAc and ME Tilia extracts significantly decreased the severity of phase 1 and phase 2 seizures, respectively. The ME Tilia extract increased the latency to seizure (27 ± 2 min) compared to the control (13 ± 2 min). The ME and EAc Tilia extracts significantly prevented the increased lipid peroxidation caused by KA-induced seizures in the cerebellum, brain hemispheres, cortex, medulla, liver, and kidneys. The vehicle olive oil (OO) also showed anticonvulsant effects, decreasing the severity of seizures to phase 3 and lipoperoxidation levels in the cerebellum, brain hemispheres, cortex, medulla, liver, and kidneys. The anticonvulsant activity of Tilia is mediated by antioxidant effects in central and systemic areas that involve synergistic interactions among the chemical constituents of these extracts (glucosides of quercetin and kaempferol), while vehicle OO showed the same effects, probably due to its constituent oleuropein.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherBrieflandses_ES
dc.relation21(1):e126914
dc.rightsAcceso Cerradoes_ES
dc.titleProtective effect of Tilia americana var. mexicana against kainic acid-induced damage in brain, liver, and kidney: behavioral and biochemical changeses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratory of Neuroscience, National Institute of Pediatrics, Mexico City, Mexico
dc.contributor.emailc_apariccio@yahoo.com.mx ; evag@imp.edu.mx
dc.relation.jnabreviadoIRAN J PHARM RES
dc.relation.journalIranian Journal of Pharmaceutical Research
dc.identifier.placePaíses Bajos
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1726-6890
dc.identifier.doihttps://doi.org/10.5812/ijpr-126914
dc.subject.kwTilia americana var. mexicana
dc.subject.kwAntioxidants
dc.subject.kwKainic Acid
dc.subject.kwLipid Peroxides
dc.subject.kwSeizures


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