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Association between CLOCK gene polymorphisms and ADHD in Mexican teenagers: a comprehensive assessment

dc.creatorCabrera Lagunes, Alfonsoes_ES
dc.creatorDíaz-Anzaldúa, Adrianaes_ES
dc.creatorRojas Andrade, Gustavoes_ES
dc.creatorPeschard, Vanessa-Gisellees_ES
dc.creatorArias Caballero, Adrianaes_ES
dc.creatorGaspar-Barba, César Enriquees_ES
dc.creatorYunes Jimenez, Arlettees_ES
dc.creatorPeña Olvera, Francisco Rafael De laes_ES
dc.creatorCruz Fuentes, Carlos Sabases_ES
dc.creatorFeria-Aranda, Miriames_ES
dc.creatorSosa Mora, Lizes_ES
dc.creatorPérez Molina, Armandoes_ES
dc.creatorGuizar Sanchez, Dianaes_ES
dc.creatorPalacios-Cruz, Linoes_ES
dc.date2022
dc.date.accessioned2024-12-23T18:30:56Z
dc.date.available2024-12-23T18:30:56Z
dc.date.issued2022
dc.identifierOE19IC22es_ES
dc.identifier.issn0165-1781
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8183
dc.identifier.urihttps://doi.org/10.1016/j.psychres.2022.114835
dc.descriptionThis study aimed to evaluate markers of the CLOCK gene rs1801260 and rs4864548 in Mexican adolescents, addressing clinical and biological aspects previously associated with ADHD. 347 Mexican adolescents were assessed for mental disorders, metabolic disruption and related conditions, circadian preference, as well as genotyping for the CLOCK. We found a significant association between ADHD and the AA and AG genotypes of rs1801260. Also, we identified in the ADHD group that the total Triiodothyronine and total Thyroxine values were respectively 10 ng/dl units and 0.58 ug/dl units lower in females than in males. Previously reported common variations of the CLOCK gene have been associated with ADHD like the Rs1801260 polymorphism hereby we could consider it as risk factor, but genetic, biochemical and clinical studies in the Mexican population are entailed.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevier/North-Holland Biomedical Presses_ES
dc.relation317:114835
dc.rightsAcceso Cerradoes_ES
dc.titleAssociation between CLOCK gene polymorphisms and ADHD in Mexican teenagers: a comprehensive assessmentes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationComprehensive Wellbeing Program, Adolescent Clinic, Division of Clinical Services, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City 14370, Mexico
dc.contributor.emailpalacioslino@gmail.com (L. Palacios-Cruz)
dc.relation.jnabreviadoPSYCHIATRY RES
dc.relation.journalPsychiatry Research
dc.identifier.placeIrlanda
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1872-7123
dc.identifier.doi10.1016/j.psychres.2022.114835
dc.subject.kwAttention deficit disorder with hyperactivity
dc.subject.kwRisk factors
dc.subject.kwGenotype
dc.subject.kwSingle nucleotide polymorphism
dc.subject.kwCircadian rhythm
dc.subject.kwTriiodothyronine
dc.subject.kwThyroxine


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