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Environmental enrichment differentially activates neural circuits in FVB/N mice, inducing social interaction in females but agonistic behavior in males

dc.creatorCabrera-Muñoz, Edith Aracelies_ES
dc.creatorOlvera-Hernández, Sandraes_ES
dc.creatorVega-Rivera, Nelly Maritzaes_ES
dc.creatorMeneses-San Juan, Davides_ES
dc.creatorReyes-Haro, Danieles_ES
dc.creatorOrtiz-López, Leonardoes_ES
dc.creatorRamírez Rodríguez, Gerardo Bernabées_ES
dc.date2022
dc.date.accessioned2024-12-23T16:34:21Z
dc.date.available2024-12-23T16:34:21Z
dc.date.issued2022
dc.identifierOE17IC22es_ES
dc.identifier.issn0364-3190
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8181
dc.identifier.urihttps://doi.org/10.1007/s11064-021-03487-8
dc.descriptionEnvironmental enrichment induces behavioral and structural modifications in rodents and influences the capability of mice to cope with stress. However, little is understood about hippocampal neurogenesis and the appearance of social/agonistic (aggressive) behavior upon activation of different neuronal circuits in FVB/N mice. Thus, in this study we hypothesized that environmental enrichment differentially regulates neurogenesis, neural circuit activation and social/agonistic behavior in male and female FVB/N mice. We explored the (1) neurogenic process as an indicative of neuroplasticity, (2) neuronal activation in the limbic system, and (3) social behavior using the resident-intruder test. On postnatal day 23 (PD23), mice were assigned to one of two groups: Standard Housing or Environmental Enrichment. At PD53, rodents underwent the resident-intruder test to evaluate social behaviors. Results revealed that environmental enrichment increased neurogenesis and social interaction in females. In males, environmental enrichment increased neurogenesis and agonistic behavior. Enriched male mice expressed higher levels of agonistic-related behavior than female mice housed under the same conditions. Neural circuit analysis showed lower activation in the amygdala of enriched males and higher activation in enriched females than their respective controls. Enriched females also showed higher activation in the frontal cortex without differences in male groups. Moreover, the insular cortex was less activated in females than in males. Thus, our results indicate that environmental enrichment has different effects on neuroplasticity and social/agonistic behavior in FVB/N mice, suggesting the relevance of sexual dimorphism in response to environmental stimuli.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherKluwer Academic/Plenum Publisherses_ES
dc.relation47(3):781-794
dc.rightsAcceso Cerradoes_ES
dc.titleEnvironmental enrichment differentially activates neural circuits in FVB/N mice, inducing social interaction in females but agonistic behavior in maleses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio of Neurogénesis, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría "Ramón de La Fuente Muñiz", Calzada México-Xochimilco No. 101, Colonia San Lorenzo Huipulco, Delegación Tlalpan, C.P. 14370, México City, México
dc.contributor.emailgbernabe@imp.edu.mx (Gerardo Bernabé Ramírez Rodríguez)
dc.relation.jnabreviadoNEURICHEM RES
dc.relation.journalNeurochemical Research
dc.identifier.placeEstados Unidos
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1573-6903
dc.identifier.doi10.1007/s11064-021-03487-8
dc.subject.kwEnvironmental enrichment
dc.subject.kwNeurogenesis
dc.subject.kwHippocampus
dc.subject.kwSocial behavior
dc.subject.kwAgonistic behavior
dc.subject.kwNeuronal activation
dc.subject.kwFVB/N mice
dc.subject.kwAdolescence


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