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Recovery of naringin-rich flavonoid extracts from agroresidues with anxiolytic- and antidepressant-like effects in mice

dc.creatorHernández-Vázquez, Lilianaes_ES
dc.creatorCassani, Juliaes_ES
dc.creatorHeyerdahl-Viau, Ivoes_ES
dc.creatorMartínez-Casares, Rubria M.es_ES
dc.creatorLuna, Héctores_ES
dc.creatorDorantes-Barrón, Ana Maríaes_ES
dc.creatorArrieta-Báez, Danieles_ES
dc.creatorEstrada-Reyes, Rosaes_ES
dc.date2022
dc.date.accessioned2024-12-20T17:33:46Z
dc.date.available2024-12-20T17:33:46Z
dc.date.issued2022
dc.identifierJC31NC22es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8177
dc.identifier.urihttps://doi.org/10.3390/molecules27238507
dc.descriptionCitrus paradisi species belong to the Rutaceae family, and it is commonly known as grapefruit. Grapefruit consumption involves a large amount of waste that goes to landfills and produces significant pollution affecting the human health. To examine this phenomenon, we designed an efficient chemical method that recovers naringin-rich flavonoid extracts from the fresh waste of grapefruits, by using the solvent impregnation resin method (SIR) with XAD-4 amberlite and either methanol or water as elution systems. Additionally, we focused on evaluating these extracts' anxiolytic- and antidepressant-like effects in behavioral predictive paradigms in mice. According to direct Principal Component Analysis (PCA) by NMR, and Direct Injection Electrospray Ionization-Mass Spectrometry (DIESI-MS), methanol extracts obtained after resin treatment were free of coumarin compounds and evinced had a high content of naringin. Poncirin, phenylalanine, chrysin 5,7-dimethyl ether, 5,7-dimethoxy-4'-hydroxyflavanone, 2,3-dihydro-2-(4-hydroxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one, tetrahydrocurcumin, corchoionoside C, 6'-coumaroyl-1'-O-[2-(3,4-dihydroxyphenyl) ethyl]-β-D-glucopyranoside were also detected. Naringin-rich methanol extract caused a clear anxiolytic-like effect in the Elevated Plus Maze (EPM) and the Hole-Board (HBT) Tests, increasing oral doses of this extract did not produce a sedative effect. A single oral dose caused an antidepressant-like effect in the Tail Suspension Test (TST), while repeated administrations of the methanol extract elicited a robust antidepressant effect in the Forced Swimming Test (FST) in mice. Our evidence highlights the importance of bioprospecting studies of organic waste with therapeutic potentials, such as anxiety and depression disorders.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation27(23):8507
dc.rightsAcceso Cerradoes_ES
dc.titleRecovery of naringin-rich flavonoid extracts from agroresidues with anxiolytic- and antidepressant-like effects in micees_ES
dc.contributor.affiliationDepartamento de Sistemas Biológicos, Universidad Autónoma Metropolitana, Unidad Xochimilco, Ciudad de México C.P. 04690, Mexico
dc.contributor.emailrestrada@imp.edu.mx
dc.relation.jnabreviadoMOLECULES
dc.relation.journalMolecules
dc.identifier.placeSuiza
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1420-3049
dc.identifier.doi10.3390/molecules27238507
dc.subject.kwNaringin
dc.subject.kwFlavonoids
dc.subject.kwAnxiety
dc.subject.kwDepression
dc.subject.kwOrganic waste
dc.subject.kwAgroresidues


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