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Pharmacological interaction of quercetin derivatives of tilia americana and clinical drugs in experimental fibromyalgia

dc.creatorQuinto-Ortiz, Yara Elenaes_ES
dc.creatorGonzález-Trujano, María Evaes_ES
dc.creatorSánchez-Jaramillo, Edithes_ES
dc.creatorMoreno-Pérez, Gabriel Fernandoes_ES
dc.creatorJacinto-Gutiérrez, Salomónes_ES
dc.creatorPellicer, Franciscoes_ES
dc.creatorFernández-Guasti, Alonsoes_ES
dc.creatorHernandez-Leon, Albertoes_ES
dc.date2022
dc.date.accessioned2024-12-19T20:56:41Z
dc.date.available2024-12-19T20:56:41Z
dc.date.issued2022
dc.identifierJC29NC22es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8176
dc.identifier.urihttps://doi.org/10.3390/metabo12100916
dc.descriptionFibromyalgia (FM) is a pain syndrome characterized by chronic widespread pain and CNS comorbidities. Tilia americana var. mexicana is a medicinal species used to treat anxiety, insomnia, and acute or chronic pain. However, its spectrum of analgesic efficacy for dysfunctional pain is unknown. To investigate a possible therapeutic alternative for FM-type pain, an aqueous Tilia extract (TE) and its flavonoid fraction (FF) containing rutin and isoquercitrin were evaluated alone and/or combined with clinical drugs (tramadol-TRA and pramipexol-PRA) using the reserpine-induced FM model in rats. Chromatographic analysis allowed the characterization of flavonoids, while a histological analysis confirmed their presence in the brain. TE (10-100 mg/kg, i.p.) and FF (10-300 mg/kg, i.p.) produced significant and dose-dependent antihyperalgesic and antiallodynic effects equivalent to TRA (3-10 mg/kg, i.p.) or PRA (0.01-1 mg/kg, s.c.). Nevertheless, the combination of FF + TRA or FF + PRA resulted in an antagonistic interaction by possible competitive action on the serotonin transporter or µ-opioid and D2 receptors, respectively, according to the in silico analysis. Flavonoids were identified in cerebral regions because of their self-epifluorescence. In conclusion, Tilia possesses potential properties to relieve FM-type pain. However, the consumption of this plant or flavonoids such as quercetin derivatives in combination with analgesic drugs might reduce their individual benefits.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation12(10):916
dc.rightsAcceso Cerradoes_ES
dc.titlePharmacological interaction of quercetin derivatives of tilia americana and clinical drugs in experimental fibromyalgiaes_ES
dc.contributor.affiliationLaboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Mexico City 14370, Mexico
dc.contributor.emailevag@imp.edu.mx (M.E.G.-T.); albertoh-leon@imp.edu.mx (A.H.-L.)
dc.relation.jnabreviadoMETABOLITES
dc.relation.journalMetabolites
dc.identifier.placeSuiza
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn2218-1989
dc.identifier.doi10.3390/metabo12100916
dc.subject.kwFibromyalgia
dc.subject.kwAntinociception
dc.subject.kwReserpine-induced myalgia
dc.subject.kwTilia americana var. mexicana
dc.subject.kwFlavonoids


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