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Insights into myelin dysfunction in schizophrenia and bipolar disorder

dc.creatorValdés-Tovar, Marcelaes_ES
dc.creatorRodríguez-Ramírez, Alejandra Monserrates_ES
dc.creatorRodríguez-Cárdenas, Leslyees_ES
dc.creatorSotelo-Ramírez, Carlo E.es_ES
dc.creatorCamarena, Beatrizes_ES
dc.creatorSanabrais-Jiménez, Marco Antonioes_ES
dc.creatorSolís-Chagoyán, Héctores_ES
dc.creatorArgueta, Jesúses_ES
dc.creatorLópez-Riquelme, Germán Octavioes_ES
dc.date2022
dc.date.accessioned2024-12-19T20:25:12Z
dc.date.available2024-12-19T20:25:12Z
dc.date.issued2022
dc.identifierOE15IC22es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8174
dc.identifier.urihttps://doi.org/10.5498/wjp.v12.i2.264
dc.descriptionSchizophrenia and bipolar disorder are disabling psychiatric disorders with a worldwide prevalence of approximately 1%. Both disorders present chronic and deteriorating prognoses that impose a large burden, not only on patients but also on society and health systems. These mental illnesses share several clinical and neurobiological traits; of these traits, oligodendroglial dysfunction and alterations to white matter (WM) tracts could underlie the disconnection between brain regions related to their symptomatic domains. WM is mainly composed of heavily myelinated axons and glial cells. Myelin internodes are discrete axon-wrapping membrane sheaths formed by oligodendrocyte processes. Myelin ensheathment allows fast and efficient conduction of nerve impulses through the nodes of Ranvier, improving the overall function of neuronal circuits. Rapid and precisely synchronized nerve impulse conduction through fibers that connect distant brain structures is crucial for higher-level functions, such as cognition, memory, mood, and language. Several cellular and subcellular anomalies related to myelin and oligodendrocytes have been found in postmortem samples from patients with schizophrenia or bipolar disorder, and neuroimaging techniques have revealed consistent alterations at the macroscale connectomic level in both disorders. In this work, evidence regarding these multilevel alterations in oligodendrocytes and myelinated tracts is discussed, and the involvement of proteins in key functions of the oligodendroglial lineage, such as oligodendrogenesis and myelination, is highlighted. The molecular components of the axo-myelin unit could be important targets for novel therapeutic approaches to schizophrenia and bipolar disorder.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherBaishideng Publishing Groupes_ES
dc.relation12(2):264-285
dc.rightsAcceso Cerradoes_ES
dc.titleInsights into myelin dysfunction in schizophrenia and bipolar disorderes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartamento de Farmacogenética, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City 14370, Mexico
dc.contributor.emailmvaldes@imp.edu.mx (Marcela Valdés-Tovar)
dc.relation.jnabreviadoWORLD J PSYCHIATRY
dc.relation.journalWorld Journal of Psychiatry.
dc.identifier.placeEstados Unidos
dc.date.published2022
dc.identifier.eissn2220-3206
dc.identifier.doi10.5498/wjp.v12.i2.264
dc.subject.kwBipolar disorder
dc.subject.kwMyelin sheath
dc.subject.kwOligodendroglia
dc.subject.kwSchizophrenia
dc.subject.kwWhite matter


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