Mostrar el registro sencillo del ítem

The nucleus accumbens dopamine increase, typically triggered by sexual stimuli in male rats, is no longer produced when animals are sexually inhibited due to sexual satiety

dc.creatorCanseco-Alba, Anaes_ES
dc.creatorCoffeen, Uliseses_ES
dc.creatorJaimes, Orlandoes_ES
dc.creatorPellicer, Franciscoes_ES
dc.creatorRodríguez-Manzo, Gabrielaes_ES
dc.date2022
dc.date.accessioned2024-12-19T19:43:32Z
dc.date.available2024-12-19T19:43:32Z
dc.date.issued2022
dc.identifierJC26NC22es_ES
dc.identifier.issn0033-3158
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8172
dc.identifier.urihttps://doi.org/10.1007/s00213-022-06240-3
dc.descriptionRationale: Exposure of male rats to an inaccessible receptive female and copulation increases dopamine (DA) levels in the nucleus accumbens (NAcc). Males copulating to satiety become sexually inhibited and most of them do not display sexual activity when presented with a sexually receptive female 24 h later. This inhibitory state can be pharmacologically reversed. There are no studies exploring NAcc DA levels during this sexual inhibitory state. Objectives: To characterize changes in NAcc DA and its metabolites' levels during sexual satiety development, during the well-established sexual inhibitory state 24 h later, and during its pharmacological reversal. Methods: Changes in NAcc DA and its metabolites were measured in sexually experienced male rats, using in vivo microdialysis, during copulation to satiety, when presented to a new sexually receptive female 24 h later, and during the pharmacological reversal of the sexual inhibition by anandamide. Results: NAcc DA levels remained increased during copulation to satiety. DA basal levels were significantly reduced 24 h after copulation to satiety, as compared to the initial basal levels. Presenting a receptive female behind a barrier 24 h after satiety did not induce the typical NAcc DA elevation in the sexually satiated males but there was a decrease that persisted when they got access to the female, with which they did not copulate. Anandamide injection slightly increased NAcc DA levels coinciding with sexual satiety reversal. Conclusions: Reduced NAcc DA concentrations coincide with the inhibition of an instinctive, natural rewarding behavior suggesting that there might be a DA concentration threshold needed to be responsive to a rewarding stimulus.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.relation239(11):3679-3695
dc.rightsAcceso Cerradoes_ES
dc.titleThe nucleus accumbens dopamine increase, typically triggered by sexual stimuli in male rats, is no longer produced when animals are sexually inhibited due to sexual satietyes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDirección de Investigación, Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez, " Av. Insurgentes Sur 3877, Col. La Fama, 14269, Mexico City, Mexico
dc.contributor.emailana.canseco@innn.edu.mx (Ana Canseco-Alba), grodrigu@cinvestav.mx (Gabriela Rodríguez-Manzo)
dc.relation.jnabreviadoPSYCHOPHARMACOLOGY
dc.relation.journalPsychopharmacology
dc.identifier.placeAlemania
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1432-2072
dc.identifier.doi10.1007/s00213-022-06240-3
dc.subject.kwNucleus accumbens
dc.subject.kwDopamine extracellular concentrations
dc.subject.kwMicrodialysis
dc.subject.kwNatural reward
dc.subject.kwMale sexual behavior
dc.subject.kwSexual satiety
dc.subject.kwSexual inhibition
dc.subject.kwSexual motivation
dc.subject.kwAnandamide
dc.subject.kwMesolimbic system


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem