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Vortioxetine treatment decreases cocaine-induced locomotor sensitization in rats

dc.creatorBarbosa-Méndez, Susanaes_ES
dc.creatorPerez-Sánchez, Gilbertoes_ES
dc.creatorSalazar-Juárez, Albertoes_ES
dc.date2022
dc.date.accessioned2024-12-19T18:55:39Z
dc.date.available2024-12-19T18:55:39Z
dc.date.issued2022
dc.identifierJC26DIEP22es_ES
dc.identifier.issn0031-9384
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8171
dc.identifier.urihttps://doi.org/10.1016/j.physbeh.2022.113989
dc.descriptionVortioxetine is a serotoninergic multi-target antidepressant, approved to treat major depressive disorder, and carries out its behavioral, pharmacological, and physiological effects through the blocking of serotonin 5-HT1D, 5-HT3, and 5-HT7 receptors and by activating 5-HT1A receptors. Some studies report that the simultaneous activation of the 5-HT1A serotonin receptors or blockade of 5-HT3 serotonin receptors decreased cocaine-induced locomotor activity and cocaine self-administration. Recent studies showed that vortioxetine decreased alcohol consumption. This studio aimed to evaluate the effects of vortioxetine dosing on cocaine-induced behavioral (cocaine-induced locomotor activity and cocaine-induced locomotor sensitization) and neurochemical (dopamine levels) effects. Male Wistar rats received cocaine during the induction and expression of locomotor sensitization. Vortioxetine was administered 30 min before cocaine. After each treatment, the locomotor activity was recorded for 30 min. Dopamine levels were determined in the ventral striatum, the prefrontal cortex (PFC), and the ventral tegmental area (VTA) by high-performance liquid chromatographic (HPLC) in animals treated with vortioxetine and cocaine. In this study, we found that vortioxetine decreased cocaine-induced locomotor activity, as well as the induction and expression of locomotor sensitization. As well as the amount of cocaine-induced dopamine decreased. Vortioxetine can be a useful therapeutic agent to reduce cocaine abuse.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation257:113989
dc.rightsAcceso Cerradoes_ES
dc.titleVortioxetine treatment decreases cocaine-induced locomotor sensitization in ratses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationSubdirección de Investigaciones Clínicas. Laboratorio de Neurofarmacología Conductual, Microcirugía y Terapéutica Experimental
dc.contributor.emailazazel_vamp@yahoo.com.mx (A. Salazar-Juárez)
dc.relation.jnabreviadoPHYSIOL BEHAV
dc.relation.journalPhysiology and Behavior
dc.identifier.placeEstados Unidos
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1873-507X
dc.identifier.doi10.1016/j.physbeh.2022.113989
dc.subject.kwVortioxetine
dc.subject.kwCocaine
dc.subject.kwLocomotor activity
dc.subject.kwLocomotor sensitization
dc.subject.kwMulti-target antidepressant


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