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Altered neutrophil-to-lymphocyte ratio in sepsis secondary to canine parvoviral enteritis treated with and without an immunomodulator in puppies

dc.creatorMuñoz, Adriana I.es_ES
dc.creatorMaldonado-Garcia, José Luises_ES
dc.creatorFragozo, Anaes_ES
dc.creatorVallejo-Castillo, Luises_ES
dc.creatorLucas-Gonzalez, Amellallies_ES
dc.creatorTrejo-Martínez, Ismaeles_ES
dc.creatorPavón, Lenines_ES
dc.creatorPérez-Sánchez, Gilbertoes_ES
dc.creatorCobos-Marin, Lauraes_ES
dc.creatorPérez-Tapia, Sonia Mayraes_ES
dc.date2022
dc.date.accessioned2024-12-19T18:09:44Z
dc.date.available2024-12-19T18:09:44Z
dc.date.issued2022
dc.identifierJC25NC22es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8170
dc.identifier.urihttps://doi.org/10.3389/fvets.2022.995443
dc.descriptionNeutrophil-to-lymphocyte ratio (NLR) is a cheap and easy-to-obtain biomarker that mirrors the balance between innate and adaptive immunity. Cortisol and catecholamines have been identified as major drivers of NLR. High cortisol levels increase neutrophils while simultaneously decreasing lymphocyte counts. Likewise, endogenous catecholamines may cause leukocytosis and lymphopenia. Thus, NLR allows us to monitor patient severity in conditions such as sepsis. Twenty-six puppies with sepsis secondary to canine parvoviral enteritis were treated with and without an immunomodulator. Our group determined the NLR and the plasmatic cortisol levels by chemiluminescence, and norepinephrine (NE) and epinephrine (E) by HPLC during the first 72 h of clinical follow-up. Our results showed that at admission puppies presented an NLR value of 1.8, cortisol of 314.9 nmol/L, NE 3.7, and E 3.3 pmol/mL. Both treatments decreased admission NLR values after 24 h of treatment. However, only the puppies treated with the immunomodulator (I) remained without significant changes in NLR (0.7-1.4) compared to the CT group, and that showed a significant difference (P < 0.01) in their NLR value (0.4-4.6). In addition, we found significant differences in the slope values between the admission and final values of NLR (P < 0.005), cortisol (P < 0.02), and E (P < 0.05) between treatments. Then, our data suggest that the immunomodulator positively affects the number of lymphocytes and neutrophils involved in NLR as well as major drivers like cortisol and epinephrine, which is reflected in clinical parameters and survival.es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Mediaes_ES
dc.relation9:995443
dc.rightsAcceso Cerradoes_ES
dc.titleAltered neutrophil-to-lymphocyte ratio in sepsis secondary to canine parvoviral enteritis treated with and without an immunomodulator in puppieses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationUnidad de Desarrollo e Investigación en Bioterapéuticos (UDIBI), Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico
dc.contributor.emaillkuriaki@imp.edu.mx (Lenin Pavón); sperezt@ipn.mx (Sonia Mayra Pérez-Tapia)
dc.relation.jnabreviadoFRONT VET SCI
dc.relation.journalFrontiers in Veterinary Science
dc.identifier.placeSuiza
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn2297-1769
dc.identifier.doi10.3389/fvets.2022.995443
dc.subject.kwCanine parvoviral enteritis
dc.subject.kwNeutrophils
dc.subject.kwLymphocytes
dc.subject.kwCortisol
dc.subject.kwEpinephrine
dc.subject.kwNorepinephrine
dc.subject.kwHuman dialyzable leucocytes extrac


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