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Antinociceptive and gastroprotective activities of Bocconia arborea S. Watson and its bioactive metabolite dihydrosanguinarine in murine models

dc.creatorGaona-Tovar, Emmanueles_ES
dc.creatorEstrada-Soto, Samueles_ES
dc.creatorGonzález-Trujano, María Evaes_ES
dc.creatorMartínez-Vargas, Davides_ES
dc.creatorHernandez-Leon, Albertoes_ES
dc.creatorNarváez-González, Fernandoes_ES
dc.creatorVillalobos-Molina, Rafaeles_ES
dc.creatorAlmanza-Pérez, Julio C.es_ES
dc.date2022
dc.date.accessioned2024-12-18T20:24:52Z
dc.date.available2024-12-18T20:24:52Z
dc.date.issued2022
dc.identifierJC24NC22es_ES
dc.identifier.issn0378-8741
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8166
dc.identifier.urihttps://doi.org/10.1016/j.jep.2022.115492
dc.descriptionEthnopharmacological relevance: Bocconia arborea S. Watson (Papaveraceae) is known as "palo llora sangre" and is used in Mexican traditional medicine for the treatment of infections, it is also used as anxiolytic, analgesic, and antidiabetic, among others. Aim of the study: to evaluate the antinociceptive and gastroprotective activities of extracts from B. arborea and dihydrosanguinarine (DHS) in murine models. Materials and methods: Organic extracts [hexane (HEX), dichloromethane (DCM) and methanol (MeOH)] were obtained by maceration. DHS was isolated and purified from HEX and DCM by precipitation and chromatographic column, respectively. Organic extracts and DHS were evaluated to determine their antinociceptive effect using formalin test in murine model. Also, the ambulatory effect of the HEX and DHS was determined in Open field test. The possible mechanism of action of DHS was explored in the presence of naltrexone (NTX, 1 mg/kg, i.p.), and picrotoxin (PTX, 1 mg/kg, i.p.). Gastric damage as possible adverse effect or gastroprotection were also investigated. Whereas DHS acute toxicological study was done, and 100 mg/kg of DHS was examined by electroencephalographic (EEG) analysis to discard neurotoxic effects. Results: The B. arborea extracts significantly showed effects in both neurogenic and inflammatory phases of the formalin test, where the HEX extract reached the major antinociceptive effect. A significant and dose-response (10, 30, and 100 mg/kg) antinociceptive activity was observed with the HEX (ED50 = 69 mg/kg) and DHS (ED50 = 85 mg/kg) resembling the effect of the reference analgesic drug tramadol (30 mg/kg). The significant effect of DHS was inhibited in the presence of NTX and PTX. Neither the extracts or DHS produced sedative effects or gastric damage per se at antinociceptive doses. The EEG analysis demonstrated central depressant activity but not sedative or neurotoxic effects at the highest antinociceptive dosage tested, and LD50 is higher than 2000 mg/kg. Conclusions: HEX, DCM, and MeOH extracts showed significant antinociceptive activity, and DHS was identified as one of bioactive compounds without producing sedative, neurotoxic or gastric damage effects, as possible adverse effects reported for analgesic drugs. A role of opioid and GABAA neurotransmission appears to be involved as mechanisms of action of DHS, suggesting its potential for pain therapy and reinforcing the traditional use of B. arborea.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation296:115492
dc.rightsAcceso Cerradoes_ES
dc.titleAntinociceptive and gastroprotective activities of Bocconia arborea S. Watson and its bioactive metabolite dihydrosanguinarine in murine modelses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationFacultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, 62209, Mexico
dc.contributor.emailenoch@uaem.mx (S. Estrada-Soto), evag@imp.edu.mx (M.E. Gonzalez-Trujano)
dc.relation.jnabreviadoJ ETHNOPHARMACOL
dc.relation.journalJournal of Ethnopharmacology
dc.identifier.placeIrlanda
dc.identifier.placeIrlanda
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1872-7573
dc.identifier.doi10.1016/j.jep.2022.115492
dc.subject.kwAnti-inflammatory
dc.subject.kwAntinociceptive
dc.subject.kwBenzophenanthridine
dc.subject.kwBocconia arborea
dc.subject.kwDihydrosanguinarine


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