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Could lower testosterone in older men explain higher COVID-19 morbidity and mortalities?

dc.creatorMontaño, Luis M.es_ES
dc.creatorSommer, Bettinaes_ES
dc.creatorSolís-Chagoyán, Héctores_ES
dc.creatorRomero-Martínez, Bianca S.es_ES
dc.creatorAquino-Gálvez, Arnoldoes_ES
dc.creatorGomez-Verjan, Juan C.es_ES
dc.creatorCalixto, Eduardoes_ES
dc.creatorGonzález-Avila, Georginaes_ES
dc.creatorFlores-Soto, Edgares_ES
dc.date2022
dc.date.accessioned2024-12-18T18:35:32Z
dc.date.available2024-12-18T18:35:32Z
dc.date.issued2022
dc.identifierJC21NC22es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8164
dc.identifier.urihttps://doi.org/10.3390/ijms23020935
dc.descriptionThe health scourge imposed on humanity by the COVID-19 pandemic seems not to recede. This fact warrants refined and novel ideas analyzing different aspects of the illness. One such aspect is related to the observation that most COVID-19 casualties were older males, a tendency also noticed in the epidemics of SARS-CoV in 2003 and the Middle East respiratory syndrome in 2012. This gender-related difference in the COVID-19 death toll might be directly involved with testosterone (TEST) and its plasmatic concentration in men. TEST has been demonstrated to provide men with anti-inflammatory and immunological advantages. As the plasmatic concentration of this androgen decreases with age, the health benefit it confers also diminishes. Low plasmatic levels of TEST can be determinant in the infection's outcome and might be related to a dysfunctional cell Ca2+ homeostasis. Not only does TEST modulate the activity of diverse proteins that regulate cellular calcium concentrations, but these proteins have also been proven to be necessary for the replication of many viruses. Therefore, we discuss herein how TEST regulates different Ca2+-handling proteins in healthy tissues and propose how low TEST concentrations might facilitate the replication of the SARS-CoV-2 virus through the lack of modulation of the mechanisms that regulate intracellular Ca2+ concentrations.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation23(2):935
dc.rightsAcceso Cerradoes_ES
dc.titleCould lower testosterone in older men explain higher COVID-19 morbidity and mortalities?es_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de Mexico, Mexico City 04510, Mexico
dc.contributor.emailedgarfs@comunidad.unam.mx
dc.relation.jnabreviadoINT J MOL SCI
dc.relation.journalInternational Journal of Molecular Sciences
dc.identifier.placeSuiza
dc.date.published2022
dc.identifier.organizacionInstituto nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1422-0067
dc.identifier.doi10.3390/ijms23020935
dc.subject.kwTestosterone
dc.subject.kwCOVID-19
dc.subject.kwSARS-CoV-2
dc.subject.kwViral replication
dc.subject.kwCalcium regulation
dc.subject.kwAging
dc.subject.kwInflammaging


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