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Environmental pollution to blame for depressive disorder?

dc.creatorSegovia-Mendoza, Marianaes_ES
dc.creatorPalacios-Arreola, Margarita Isabeles_ES
dc.creatorPavón, Lenines_ES
dc.creatorBecerril, Luis Enriquees_ES
dc.creatorNava-Castro, Karen Elizabethes_ES
dc.creatorAmador-Muñoz, Omares_ES
dc.creatorMorales-Montor, Jorgees_ES
dc.date2022
dc.date.accessioned2024-12-16T18:51:53Z
dc.date.available2024-12-16T18:51:53Z
dc.date.issued2022
dc.identifierJC18NC22es_ES
dc.identifier.issn1661-7827
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8161
dc.identifier.urihttps://doi.org/10.3390/ijerph19031737
dc.descriptionPublic concern has emerged about the effects of endocrine-disrupting compounds (EDCs) on neuropsychiatric disorders. Preclinical evidence suggests that exposure to EDCs is associated with the development of major depressive disorder (MDD) and could result in neural degeneration. The interaction of EDCs with hormonal receptors is the best-described mechanism of their biological activity. However, the dysregulation of the hypothalamic-pituitary-gonadal adrenal axis has been reported and linked to neurological disorders. At a worldwide level and in Mexico, the incidence of MDD has recently been increasing. Of note, in Mexico, there are no clinical associations on blood levels of EDCs and the incidence of the MDD. Methodology: Thus, we quantified for the first time the serum levels of parent compounds of two bisphenols and four phthalates in patients with MDD. The levels of di-ethyl-hexyl-phthalate (DEHP), butyl-benzyl-phthalate (BBP), di-n-butyl phthalate (DBP), and di-ethyl-phthalate (DEP), bisphenol A (BPA), and bisphenol S (BPS) in men and women with or without MDD were determined with a gas chromatograph-mass spectrometer. Results/conclusion: We found significant differences between concentrations of BBP between controls and patients with MDD. Interestingly, the serum levels of this compound have a dysmorphic behavior, being much higher in women (~500 ng/mL) than in men (≤10 ng/mL). We did not observe significant changes in the serum concentrations of the other phthalates or bisphenols tested, neither when comparing healthy and sick subjects nor when they were compared by gender. The results point out that BBP has a critical impact on the etiology of MDD disorder in Mexican patients, specifically in women.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation19(3):1737
dc.rightsAcceso Cerradoes_ES
dc.titleEnvironmental pollution to blame for depressive disorder?es_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de Mexico 04510, Mexico
dc.contributor.emailjmontor66@biomedicas.unam.mx
dc.relation.jnabreviadoINT J ENVIRON RES PUBLIC HEALTH
dc.relation.journalInternational Journal of Environmental Research and Public Health
dc.identifier.placeSuiza
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1660-4601
dc.identifier.doi10.3390/ijerph19031737
dc.subject.kwDepression
dc.subject.kwSerum levels
dc.subject.kwPhthalates
dc.subject.kwBisphenols


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