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Sexual dimorphism of the neuroimmunoendocrine response in the spleen during a helminth infection: a new role for an old player?

dc.creatorNava-Castro, Karen Elizabethes_ES
dc.creatorPavón, Lenines_ES
dc.creatorBecerril-Villanueva, Luis Enriquees_ES
dc.creatorPonce-Regalado, María Doloreses_ES
dc.creatorAguilar-Díaz, Hugoes_ES
dc.creatorSegovia-Mendoza, Marianaes_ES
dc.creatorMorales-Montor, Jorgees_ES
dc.date2022
dc.date.accessioned2024-12-12T17:10:54Z
dc.date.available2024-12-12T17:10:54Z
dc.date.issued2022
dc.identifierJC16NC22es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8159
dc.identifier.urihttps://doi.org/10.3390/pathogens11030308
dc.descriptionThe interaction of the nervous, immune, and endocrine systems is crucial in maintaining homeostasis in vertebrates, and vital in mammals. The spleen is a key organ that regulates the neuroimmunoendocrine system. The Taenia crassiceps mouse system is an excellent experimental model to study the complex host–parasite relationship, particularly sex-associated susceptibility to infection. The present study aimed to determine the changes in neurotransmitters, cytokines, sex steroids, and sex-steroid receptors in the spleen of cysticercus-infected male and female mice and whole parasite counts. We found that parasite load was higher in females in comparison to male mice. The levels of the neurotransmitter epinephrine were significantly decreased in infected male animals. The expression of IL-2 and IL-4 in the spleen was markedly increased in infected mice; however, the expression of Interleukin (IL)-10 and interferon (IFN)-γ decreased. We also observed sex-associated differences between non-infected and infected mice. Interestingly, the data show that estradiol levels increased in infected males but decreased in females. Our studies provide evidence that infection leads to changes in neuroimmunoendocrine molecules in the spleen, and these changes are dimorphic and impact the establishment, growth, and reproduction of T. crassiceps. Our findings support the critical role of the neuroimmunoendocrine network in determining sex-associated susceptibility to the helminth parasite.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherMDPI AGes_ES
dc.relation11(3):308
dc.rightsAcceso Cerradoes_ES
dc.titleSexual dimorphism of the neuroimmunoendocrine response in the spleen during a helminth infection: a new role for an old player?es_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Biología y Química Atmosférica, Departamento de Ciencias Ambientales, Instituto de Ciencias de la Atmósfera y Cambio Climático, Universidad Nacional Autónoma de México, Ciudad de Mexico 04510, Mexico
dc.contributor.emailjmontor66@biomedicas.unam.mx
dc.relation.jnabreviadoPATHOGENS
dc.relation.journalPathogens
dc.identifier.placeSuiza
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn2076-0817
dc.identifier.doi10.3390/pathogens11030308
dc.subject.kwNeuroimmunoendocrinology
dc.subject.kwSpleen
dc.subject.kwParasite immunity
dc.subject.kwSexual dimorphism
dc.subject.kwNeurotransmitters
dc.subject.kwCytokines
dc.subject.kwHelminths
dc.subject.kwCysticercosis
dc.subject.kwTaenia crassiceps
dc.subject.kwImmunity
dc.subject.kwInfection


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