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A review on the ethnopharmacology and phytochemistry of the neotropical sages (salvia subgenus calosphace; lamiaceae) emphasizing Mexican species

dc.creatorOrtiz-Mendoza, Nancyes_ES
dc.creatorAguirre-Hernández, Evaes_ES
dc.creatorFragoso-Martínez, Itzies_ES
dc.creatorGonzález-Trujano, María Evaes_ES
dc.creatorBasurto-Peña, Francisco A.es_ES
dc.creatorMartínez-Gordillo, Martha J.es_ES
dc.date2022
dc.date.accessioned2024-12-11T20:20:59Z
dc.date.available2024-12-11T20:20:59Z
dc.date.issued2022
dc.identifierJC15NC22es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8157
dc.identifier.urihttps://doi.org/10.3389/fphar.2022.867892
dc.descriptionSalvia is the most diverse genus within the mint family (Lamiaceae), many of its species are well-known due to their medicinal and culinary uses. Most of the ethnopharmacological and phytochemical studies on Salvia are centred on species from the European and Asian clades. However, studies about the most diverse clade, the Neotropical sages (Salvia subgenus Calosphace; 587 spp.), are relatively scarce. This review aims to compile the information on the traditional medicinal uses, pharmacological and phytochemistry properties of the Neotropical sages. To do so, we carried out a comprehensive review of the articles available in different online databases published from the past to 2022 (i.e., PubMed, Scopus, and Web of Science, among others) and summarized the information in tables. To uncover phylogenetic patterns in the distribution of four different groups of metabolites (mono-, sesqui-, di-, and triterpenes), we generated presence-absence matrices and plotted the tip states over a dated phylogeny of Salvia. We found several studies involving Mexican species of Salvia, but only a few about taxa from other diversity centres. The main traditional uses of the Mexican species of Calosphace are medicinal and ceremonial. In traditional medicine 56 species are used to treat diseases from 17 categories according to the WHO, plus cultural-bound syndromes. Pharmacological studies reveal a wide range of biological properties (e.g., antinociceptive, anti-inflammatory, anxiolytic, cytotoxic, and antidiabetic, etc.) found in extracts and isolated compounds of 38 Neotropical sages. From extracts of these species, at least 109 compounds have been isolated, identified and evaluated pharmacologically; 73 of these compounds are clerodanes, 21 abietanes, six flavonoids, five sesquiterpenoids, and four triterpenoids. The most characteristic metabolites found in the Neotropical sages are the diterpenes, particularly clerodanes (e.g., Amarisolide A, Tilifodiolide), that are found almost exclusively in this group. The Neotropical sages are a promising resource in the production of herbal medication, but studies that corroborate the properties that have been attributed to them in traditional medicine are scarce. Research of these metabolites guided by the phylogenies is recommended, since closely related species tend to share the presence of similar compounds and thus similar medicinal properties.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherFrontiers Mediaes_ES
dc.relation13:867892
dc.rightsAcceso Cerradoes_ES
dc.titleA review on the ethnopharmacology and phytochemistry of the neotropical sages (salvia subgenus calosphace; lamiaceae) emphasizing Mexican specieses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Productos Naturales, Departamento de Ecología y Recursos Naturales, Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, Mexico
dc.contributor.emaileva_aguirre@ciencias.unam.mx (Eva Aguirre-Hernández); itzi.fragoso@inecol.mx (Itzi Fragoso-Martínez)
dc.relation.jnabreviadoFRONT PHARMACOL
dc.relation.journalFrontiers in Pharmacology
dc.identifier.placeSuiza
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1663-9812
dc.identifier.doi10.3389/fphar.2022.867892
dc.subject.kwAbietane
dc.subject.kwBioactive compounds
dc.subject.kwClerodane
dc.subject.kwDiterpene
dc.subject.kwMexican traditional medicine


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