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GABA A /Benzodiazepine Receptor Complex in the Dorsal Hippocampus Mediates the Effects of Chrysin on Anxiety-Like Behaviour in Female Rats

dc.creatorRodríguez-Landa, Juan Franciscoes_ES
dc.creatorHernández-López, Fabiolaes_ES
dc.creatorMartínez-Mota, Lucíaes_ES
dc.creatorScuteri, Damianaes_ES
dc.creatorBernal-Morales, Blandinaes_ES
dc.creatorRivadeneyra-Domínguez, Eduardoes_ES
dc.date2022
dc.date.accessioned2024-12-09T19:20:31Z
dc.date.available2024-12-09T19:20:31Z
dc.date.issued2022
dc.identifierJC08NC22es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8147
dc.identifier.urihttps://doi.org/10.3389/fnbeh.2021.789557
dc.descriptionSystemic injections of the flavonoid chrysin (5,7-dihydroxyflavone) exert anxiolytic-like effects in ovariectomised and cycling female rats through actions on gamma-aminobutyric acid-A (GABA A ) receptors; however, it is unknown if chrysin directly acts on brain structures that are involved in regulating emotional processes, such as the hippocampus. The present study evaluated the effects of intrahippocampal microinjections of 0.25, 0.5, and 1 μg of chrysin on anxiety-like behaviour in the elevated plus maze (EPM) and locomotor activity test (LAT) in female rats in proestrus and dioestrus. Similar doses of the neurosteroid allopregnanolone were used as a reference GABAergic anxiolytic drug. The participation of the GABA A /benzodiazepine receptor complex was evaluated by administering the antagonists picrotoxin, bicuculline and flumazenil. In proestrus, 0.5 and 1 μg of chrysin and allopregnanolone induced anxiogenic-like behaviour. In dioestrus, chrysin, and allopregnanolone (0.5 μg) induced anxiolytic-like effects. Picrotoxin, bicuculline and flumazenil prevented the effects of chrysin and allopregnanolone in both proestrus and dioestrus. None of the treatments significantly affected locomotor activity. These results indicate that the GABA A /benzodiazepine receptor complex in the dorsal hippocampus regulates the effects of chrysin on anxiety-like behaviour, similar to the actions of allopregnanolone. The divergent effects of treatments across the oestrous cycle phases suggest complex interactions between GABA A receptors and compounds with an anxiolytic potential.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherFrontiers Research Foundationes_ES
dc.relation15:789557
dc.rightsAcceso Cerradoes_ES
dc.titleGABA A /Benzodiazepine Receptor Complex in the Dorsal Hippocampus Mediates the Effects of Chrysin on Anxiety-Like Behaviour in Female Ratses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Mexico
dc.contributor.emailjuarodriguez@uv.mx (Juan Francisco Rodríguez-Landa) ; damiana.scuteri@unical.it (Damiana Scuteri)
dc.relation.jnabreviadoFRONT BEHAV NEUROSCI
dc.relation.journalFrontiers in Behavioral Neuroscience
dc.identifier.placeSuiza
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1662-5153
dc.identifier.doi10.3389/fnbeh.2021.789557
dc.subject.kwAllopregnanolone
dc.subject.kwAnxiety
dc.subject.kwFlavonoid
dc.subject.kwGABAA receptor
dc.subject.kwOvarian cycle


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