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Can animal models resemble a premenstrual dysphoric condition?

dc.creatorEstrada-Camarena, Erikaes_ES
dc.creatorLópez-Rubalcava, Carolinaes_ES
dc.date2022
dc.date.accessioned2024-12-09T16:45:22Z
dc.date.available2024-12-09T16:45:22Z
dc.date.issued2022
dc.identifierJC04NC22es_ES
dc.identifier.issn0091-3022
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8142
dc.identifier.urihttps://doi.org/10.1016/j.yfrne.2022.101007
dc.descriptionAround 80% of women worldwide suffer mild Premenstrual Disorders (PMD) during their reproductive life. Up to a quarter are affected by moderate to severe symptoms, and between 3% and 8% experience a severe form. It is classified as premenstrual syndrome (PMS) with predominantly physical symptoms and premenstrual dysphoric disorder (PMDD) with psychiatric symptoms. The present review analyzes the factors associated with PMD and the Hypothalamus-Pituitary-Ovarian or Hypothalamus-Pituitary-adrenal axis and discusses the main animal models used to study PMDD. Evidence shows that the ovarian hormones participate in PMDD symptoms, and several points of regulation of their synthesis, metabolism, and target sites could be altered. PMDD is complex and implies several factors that require consideration when this condition is modeled in animals. Of particular interest are those points related to areas that may represent opportunities to develop new approximations to understand the mechanisms involved in PMDD and possible treatments.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation66:101007
dc.rightsAcceso Cerradoes_ES
dc.titleCan animal models resemble a premenstrual dysphoric condition?es_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Neuropsicofarmacología, Dirección de Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz." Mexico City, México
dc.contributor.emailestrada@imp.edu.mx (E.-C. Erika); clopezr@cinvestav.mx (C. Lopez-Rubalcava)
dc.relation.jnabreviadoFRONT NEUROENDOCRINOL
dc.relation.journalFrontiers in Neuroendocrinology
dc.identifier.placeEstados Unidos
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1095-6808
dc.identifier.doi10.1016/j.yfrne.2022.101007
dc.subject.kwPremenstrual disorders
dc.subject.kwAnimal models
dc.subject.kwMenstrual cycle
dc.subject.kwEstrous cycle
dc.subject.kwProgesterone
dc.subject.kwAllopregnanolone
dc.subject.kwGABAAR
dc.subject.kwHPA axis


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