Mostrar el registro sencillo del ítem

Increased levels of HbA1c in individuals with type 2 diabetes and depression: a meta-analysis of 34 studies with 68,398 participants

dc.creatorGenis-Mendoza, Alma Deliaes_ES
dc.creatorGonzález-Castro, Thelma Beatrizes_ES
dc.creatorTovilla-Vidal, Gissellees_ES
dc.creatorJuárez-Rojop, Isela Estheres_ES
dc.creatorCastillo-Avila, Rosa Gianninaes_ES
dc.creatorLópez-Narváez, María Liliaes_ES
dc.creatorTovilla-Zárate, Carlos Alfonsoes_ES
dc.creatorSánchez-de la Cruz, Juan Pabloes_ES
dc.creatorFresán, Anaes_ES
dc.creatorNicolini, Humbertoes_ES
dc.date2022
dc.date.accessioned2024-12-06T20:46:30Z
dc.date.available2024-12-06T20:46:30Z
dc.date.issued2022
dc.identifierOE07IC22es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8141
dc.identifier.urihttps://doi.org/10.3390/biomedicines10081919
dc.descriptionGlycosylated hemoglobin is used to diagnose type 2 diabetes mellitus and assess metabolic control. Depression itself has been associated with high levels of HbA1c in individuals with T2DM. The association between diabetes and depression suggests the usefulness of determining HbA1c as a biological marker of depressive symptoms. The aim of this study was to determine HbA1c levels in individuals with T2DM with vs. without depression. Additionally, we analyzed the influence of pharmacological treatments, time of evolution, and complications of disease. We performed a literature search in different databases published up to January 2020. A total of 34 articles were included. Our results showed that individuals with T2DM with depression showed increased levels of HbA1c in comparison to individuals with T2DM without depression (d = 0.18, 95% CI: 0.12−0.29, p(Z) < 0.001; I2 = 85.00). We also found that HbA1c levels remained elevated in individuals with T2DM with depression who were taking hypoglycemic drugs (d = 0.20 95% CI: 0.11−0.30, p(Z) < 0.001; I2 = 86.80), in individuals with less than 10 years of evolution (d = 0.17 95% CI: 0.09−0.26, p(Z) = 0.001; I2 = 66.03) and in individuals with complications of the disease (d = 0.17, 95% CI: 0.07−0.26, p(Z) < 0.001; I2 = 58.41). Our results show that HbA1c levels in individuals with T2DM with depression are significantly increased compared to controls with T2DM without depression. Additionally, these levels remained elevated in individuals who were taking hypoglycemic drugs, those with less than 10 years of disease evolution, and those with complications related to diabetes. It is necessary to examine the existence of a diabetes−HbA1c−depression connection.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherMDPI AGes_ES
dc.relation10(8):1919
dc.rightsAcceso Cerradoes_ES
dc.titleIncreased levels of HbA1c in individuals with type 2 diabetes and depression: a meta-analysis of 34 studies with 68,398 participantses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Genómica de Enfermedades Psiquiátricas y Neurodegenerativas, Instituto Nacional de Medicina Genómica, Ciudad de México 14610, Mexico.
dc.contributor.emailalfonso_tovillaz@yahoo.com.mx (C.A.T.-Z.) ; hnicolini@inmegen.gob.mx (H.N.)
dc.relation.jnabreviadoBIOMEDICINES
dc.relation.journalBiomedicines
dc.identifier.placeSuiza
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn2227-9059
dc.identifier.doi10.3390/biomedicines10081919
dc.subject.kwHbA1c
dc.subject.kwComplications
dc.subject.kwDepression
dc.subject.kwDiabetes
dc.subject.kwHypoglycemic drug


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem