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Intranasal methylprednisolone ameliorates neuroinflammation induced by chronic toluene exposure

dc.creatorGiraldo-Velásquez, Manuel F.es_ES
dc.creatorPérez-Osorio, Iván N.es_ES
dc.creatorEspinosa-Cerón, Alejandroes_ES
dc.creatorBárcena, Brandon M.es_ES
dc.creatorCalderón-Gallegos, Arturoes_ES
dc.creatorFragoso, Gladises_ES
dc.creatorTorres-Ramos, Mónicaes_ES
dc.creatorPáez-Martínez, Nayelies_ES
dc.creatorSciutto, Eddaes_ES
dc.date2022
dc.date.accessioned2024-12-06T19:42:21Z
dc.date.available2024-12-06T19:42:21Z
dc.date.issued2022
dc.identifierJC03NC22es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8140
dc.identifier.urihttps://doi.org/10.3390/pharmaceutics14061195
dc.descriptionInhalants are chemical substances that induce intoxication, and toluene is the main component of them. Increasing evidence indicates that a dependence on inhalants involves a state of chronic stress associated to the activation of immune cells in the central nervous system and release of proinflammatory mediators, especially in some brain areas such as the nucleus accumbens and frontal cortex, where the circuits of pleasure and reward are. In this study, anti-neuroinflammatory treatment based on a single dose of intranasal methylprednisolone was assessed in a murine model of chronic toluene exposure. The levels of proinflammatory mediators, expression levels of Iba-1 and GFAP, and histological changes in the frontal cortex and nucleus accumbens were evaluated after the treatment. The chronic exposure to toluene significantly increased the levels of TNF-α, IL-6, and NO, the expression of GFAP, and induced histological alterations in mouse brains. The treatment with intranasally administered MP significantly reduced the expression of TNF-α and NO and the expression of GFAP (p < 0.05); additionally, it reversed the central histological damage. These results indicate that intranasally administered methylprednisolone could be considered as a treatment to reverse neuroinflammation and histological damages associated with the use of inhalants.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation14(6):1195
dc.rightsAcceso Cerradoes_ES
dc.titleIntranasal methylprednisolone ameliorates neuroinflammation induced by chronic toluene exposurees_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Ciudad Universitaria, Coyoacán, Ciudad de México 04510, Mexico
dc.contributor.emailnayepam@yahoo.com.mx (N.P.-M.); edda@unam.mx (E.S.)
dc.relation.jnabreviadoPHARMACEUTICS
dc.relation.journalPharmaceutics
dc.identifier.placeSuiza
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1999-4923
dc.identifier.doi10.3390/pharmaceutics14061195
dc.subject.kwToluene
dc.subject.kwNeuroinflammation
dc.subject.kwHistological damage
dc.subject.kwIntranasal administration
dc.subject.kwMethylprednisolone


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